| Project/Area Number |
21590996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKATA Koh 新潟大学, 医歯学総合病院, 教授 (80207802)
MORIMOTO Yasuo 産業医科大学, 産業生態科学研究所, 教授 (30258628)
MATSUDA Haruo 広島大学, 生物圏科学研究科, 教授 (80116863)
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| Co-Investigator(Renkei-kenkyūsha) |
YATERA Kazuhiro 産業医科大学, 医学部, 助教 (40341515)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | オステオポンチン / トランスグルタミナーゼ / インテグリン / 肺線維症 / 重合 / 好中球 / 遺伝子改変マウス |
|---|
| Research Abstract |
Osteopontin(OPN) is involved in pulmonary fibrosis by yet unknown mechanism. We investigated if OPN polymerization leads to pulmonary fibrosis, and found followings. 1) Polymeric OPN is a chemoattractant for neutrophils in vitro, 2) integrinα9β1 recognition site is formed on polymeric OPN upon polymerization, 3) polymeric OPN is also attracts neutrophils in vivo, 4) monomeric OPN, by converting into polymer, also attracts neutrophils in vivo. These results strongly suggest polymerization of OPN can regulate tissue accumulation of neutrophils that could induce fibrosis.
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