| Project/Area Number |
21591002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIROSE Minoru 北里大学, 医療衛生学部, 教授 (50286382)
KOKUBO Kenichi 北里大学, 医療衛生学部, 准教授 (20287965)
SHINBO Toshihiro 北里大学, 医療衛生学部, 助教 (10406910)
KUBOTA Masaru 北里大学, 医学部, 准教授 (00234500)
HATAISHI Ryuji 北里大学, 医学部, 講師 (20276124)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / その他・酸素障害 / 酸素障害 / 肺障害 / 酸素 / 活性酸素 / 水素 / 一酸化窒素 / 活性酵素 |
|---|
| Research Abstract |
Survival time of mice exposed to hyperoxia became longer when the mice breathed hydrogen gas, and the leukocytes accumulation in the lungs was reduced. Hydrogen gas protected cultured human alveolar epithelial cells against antimycin A-induced oxidative stress. The level of superoxide produced by mitochondria was significantly low, and the increase in superoxide produced by antimycin A was also lower in the presence of hydrogen gas. Hydrogen gas protected lungs against hyperoxic lung injury.
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