| Project/Area Number |
21591004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
|
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Katsutoshi 東京慈恵会医科大学, 医学部, 准教授 (40321989)
ARAYA Jun 東京慈恵会医科大学, 医学部, 講師 (90468679)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 肺損傷 / 細胞老化 / アポトーシス / 特発性肺線維症 / 肺線維症 / 老化 / 肺上皮細胞 / 肺線維芽細胞 |
|---|
| Research Abstract |
We found bronchial and alveolar epithelial cell senescence in lung tissues from patients with idiopathic pulmonary fibrosis(IPF), but not fibroblast senescence. These results suggest that the difference of responsiveness to microenvironment in each type of cells leads to tissue remodeling and pulmonary fibrosis. TGF-beta induced cell senescence in human primary cultured bronchial epithelial cells and SIRT6 inhibited it. To inhibit epithelial cell senescence may leads to prevent pulmonary fibrosis.
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