Investigation on the Roles of Cathepsin S in Sarcoidosis

• Project/Area Number: 21591010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Aichi Medical University
• Principal Investigator: YAMAGUCHI Etsuro 愛知医科大学, 医学部, 教授 (10201831)
• Co-Investigator(Kenkyū-buntansha): BABA Kenji 愛知医科大学, 医学部, 教授 (80211499) ; TAKAHASHI Daisuke 愛知医科大学, 医学部, 助教 (00431370)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: サルコイドーシス・カテプシンS / アンジオテンシン転換酵素 / サルコイドーシス / カテプシンS / カテプシンD / LRAP / 間質性肺炎 / 気管支喘息 / 塵肺 / 甲状腺機能亢進症 / 肝硬変 / ROCカーブ

Research Abstract

We selected cathepsin S (CTSS) by microarray analysis of gene expression by alveolar macrophages obtained from sarcoidosis patients and compared the clinical significance of serum CTSS levels with serum activities of angiotensin converting enzyme in various diseases. We found that CTSS is superior to ACE in differentiating sarcoidosis from parenchymal lung diseases.

Research Products

• [Presentation] The role of serum cathepsin S levels in sarcoidosis. (2010)
  • Author(s): Yamaguchi E, et al.
  • Organizer: European Respiratory Society Barcelona 2010
  • Place of Presentation: Fira Barcelona (Barcelona Spain)
  • Year and Date: 2010-09-22
• [Presentation] The role of serum cathepsin S levels in sarcoidosis (2010)
  • Author(s): Yamaguchi E, et al.
  • Organizer: European Respiratory Society Barcelona 2010
  • Place of Presentation: Barcelona Spain