The effects of fatty acid emulsion for cisplatin-induced acute renal failure in rats

• Project/Area Number: 21591015
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Hirosaki University
• Principal Investigator: NAKAMURA Norio 弘前大学, 大学院・医学研究科, 准教授 (60332657)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 腎臓学 / n-3系多価不飽和脂肪酸 / 急性腎不全 / EPA / DHA / 脂肪酸乳剤 / 馬杉腎炎 / エイコサペンタエン酸 / シスプラチン / 脂肪酸分析 / ドコサヘキサエン酸

Research Abstract

In this study, we created an infusible emulsion of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and investigated the effect of the emulsion against cisplatin-induced acute renal failure model of rats. However, there were no beneficial effect of the emulsion in the model. We also investigated the effect of DHA emulsion against nephrotoxic serum nephritis model of rats. After the administration of the emulsion, the levels of protein excretion of urine were decreased in the rats. These results suggest that DHA emulsion might be beneficial effects for the renal disease.

Research Products

• [Journal Article] Thrombin stimulates synthesis of macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor by human proximal tubular epithelial cells in culture (2012)
  • Author(s): Shimaya Y, Nakamura N, et al.
  • Journal Title: Nephron Extra Volume: 2 Issue: 1 Pages: 1-8
  • DOI: 10.1159/000335751
  • Peer Reviewed
• [Journal Article] Effects of tridocosahexaenoyl-glycerol emulsion on proteinuria in rats with nephrotoxic serum nephritis (2011)
  • Author(s): Nakamura N, Kumasaka R, Y-F Lu, Fujita T, Murakami R, Shimada M, Shimaya Y, Osawa H, Yamabe H, Okumura K, Hamazaki K, Hamazaki T
  • Journal Title: Nephron Extra Volume: 1 Issue: 1 Pages: 139-146
  • DOI: 10.1159/000333479
  • Peer Reviewed
• [Journal Article] Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task (2011)
  • Author(s): Hamazaki-Fujita N, Hamazaki K, Tohno H, Itomura M, Terashima Y, Hamazaki T, Nakamura N, Yomoda S
  • Journal Title: Brain Res Volume: 1397 Pages: 38-45
  • Peer Reviewed
• [Journal Article] Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task (2011)
  • Author(s): Hamazaki-Fujita N, NakamuraN, et al.
  • Journal Title: Brain Research Volume: 1397 Pages: 38-45
  • Peer Reviewed
• [Journal Article] Clinicopathological study on hepatitis C virus-associated glomerulonephritis without hepatits C virus in the blood (2010)
  • Author(s): Yamabe H, Nakamura N, Shimada M, Murakami R, Fujita T, Shimaya Y, Kitajima M, Urushizaka M
  • Journal Title: Intern Med Volume: 49 Pages: 1321-1323
  • Peer Reviewed
• [Journal Article] Tissue factor pathway inhibitor (TFPI) production by human podocyte in culure. (2010)
  • Author(s): Yamabe H, Nakamura N, et al.
  • Journal Title: Thrombosis Research Volume: Vol.126
  • Peer Reviewed
• [Journal Article] Clinicopathological study on hepatitis C virus-associated glomerul onephritis without hepatits C virus in the blood. (2010)
  • Author(s): Yamabe H, Nakamura N, et al.
  • Journal Title: Intern Med Volume: Vol.49 Pages: 1321-1323
  • Peer Reviewed
• [Journal Article] Complications after surgery in hemodialysis patients : A comparison between diabetic and non-diabetic patients (2009)
  • Author(s): Shimoyama Y, Nakamura N, Kawaguchi T, Okumura K
  • Journal Title: Dialysis & Transplantation Volume: 38 Pages: 412-414
  • Peer Reviewed
• [Journal Article] Extracellular matrix metalloproteinase inducer is expressed in the proximal tubular epithelial cells of the human kidney (2009)
  • Author(s): Shimada M, Yamabe H, Osawa H, Nakamura N, Kumasaka R, Murakami R, Fujita T, Osanai T, Okumura K
  • Journal Title: Nephrology Volume: 14(2) Pages: 171-178
  • Peer Reviewed
• [Journal Article] CKD患者の輸液と経腸栄養の指針-ステージ4・5患者への対策.III脂肪酸輸液の指針 (2009)
  • Author(s): 中村典雄
  • Journal Title: 臨床透析 Volume: 25(13) Pages: 1795-1800
• [Journal Article] 脂肪酸輸液の指針 (2009)
  • Author(s): 中村典雄
  • Journal Title: 臨床透析 25 Pages: 1795-1800
• [Journal Article] Extracellular matrix metalloproteinase inducer is expressed in the proximal tubular epithelial cells of the human kidney. (2009)
  • Author(s): Shimada M, 中村典雄, et al.
  • Journal Title: Nephrology Vol.14 Pages: 171-178
  • Peer Reviewed
• [Journal Article] Complications after surgery in hemodialysis patients : A comparison between diabetic and non-diabetic patients. (2009)
  • Author(s): Shimoyama Y, 中村典雄, et al.
  • Journal Title: Dialysis & Transplantation Vol.38 Pages: 412-414
  • Peer Reviewed
• [Presentation] Thrombin stimulates synthesis of GM-CSF, G-CSR, M-CSF, MCP-1 and IL-8 in human proximal tubular epithelial cells in culture (2011)
  • Author(s): Shimada M, Nakamura N, et al.
  • Organizer: World Congress of Nephrology 2011
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2011-04-10
• [Presentation] Thrombin stimulates synthethis of GM-CSF, G-CSF, M-CSF, MCP-1 and IL-8 in human proximal tubular epithelial cells in culture (2011)
  • Author(s): Shimada M, Shimaya Y, Yamabe H, Fujita T, Murakami R, Nakamura N, Okumura K
  • Organizer: World Congress of Nephrology 2011
  • Place of Presentation: Vancouver, Canada
• [Presentation] Mizoribine (MZR) suppresses proliferation of rat glomerular epithelial cells (GEC) in culture and attenuates the expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) augmentes by thrombin (2011)
  • Author(s): Yamabe H, Shimada M, Murakami R, Fujita T, Shimaya Y, Nakamura N, Okumura K
  • Organizer: World Congress of Nephrology 2011
  • Place of Presentation: Vancouver, Canada
• [Presentation] 骨髄異形成症候群、胃癌に合併したANCA関連腎炎の一例 (2010)
  • Author(s): 中村典雄, 他
  • Organizer: 第40回日本腎臓学会東部学術大会(宇都宮市)
  • Place of Presentation: 栃木県総合文化センター(宇都宮市)
  • Year and Date: 2010-09-24
• [Presentation] Patholigical findings by electron microscopy in hepatitis C virus-associated glomerulonephritis (2010)
  • Author(s): Yamabe H, Nakamura N, Shimada M, Murakami R, Fujita T, Shimaya Y, Okumura K, Kaizuka M
  • Organizer: The 12th Asian Pacific Congress of Nephrology
  • Place of Presentation: Seoul, Korea
• [Presentation] シクロスポリンの培養糸球体上皮細胞の増殖ならびにMCP-1産生抑制作用について (2009)
  • Author(s): 山辺英彰、中村典雄, 他.
  • Organizer: 第52回日本腎臓学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-06-03