• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Novel hormones and receptors in renal and cardiovascular injuries.

Research Project

Project/Area Number 21591016
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionTohoku Fukushi University

Principal Investigator

TOTSUNE Kazuhito  東北福祉大学, 総合福祉学部, 教授 (10217515)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Kazuhiro  東北大学, 大学院・医学系研究科, 教授 (80241628)
IMAI Yutaka  東北大学, 大学院・薬学研究科, 教授 (40133946)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords遺伝子 / 循環器 / 高血圧 / 腎障害 / 脳血管障害 / 循環器・高血圧 / 生理活性 / 発現・制御 / プロレニン受容体
Research Abstract

Pathophysiological roles of novel hormones and receptors were examined in association with organ injuries. Expressions of adrenomedullin II(AM2) and(pro) renin receptor((P) RR) in the kidney and/or heart were significantly changed in renal failure, cardiac failure and hypertensive animal models. Analyses of gene polymorphisms revealed that the polymorphisms of AM2 and(P) RR were significantly associated with occurrences of cardiac hypertrophy, cerebral lacuna infarction and chronic kidney diseases. These results indicate that these novel hormones and receptors actually play certain roles in the renal and cardiovascular injuries.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (40 results)

All 2012 2011 2010 2009

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (19 results)

  • [Journal Article] Prognostic significance of home arterial stiffness index derived from self-measurement of blood pressure: The Ohasama study2012

    • Author(s)
      Kikuya M, Totsune K, et al
    • Journal Title

      Am J Hypertens

      Volume: 25 Issue: 1 Pages: 67

    • DOI

      10.1038/ajh.2011.167

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: The Ohasama study2011

    • Author(s)
      Hirose T, Totsune K, Nakashige Y, Metoki H, Kikuya M, Ohkubo T, Hara A, Satoh M, Inoue R, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi Shin-Ichi, Rakugi H, Takahashi K and Imai Y.
    • Journal Title

      Hypertens Res

      Volume: 34 Issue: 12 Pages: 1327

    • DOI

      10.1038/hr.2011.131

    • NAID

      10030278155

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of(pro) renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women : the Ohasama study2011

    • Author(s)
      Hirose T, Hashimoto M, Totsune K, Metoki H, Hara A, Satoh M, Kikuya M, Ohkubo T, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi S, Rakugi H, Takahashi K, Imai Y.
    • Journal Title

      Hypertens Res

      Volume: Vol.34 Pages: 530-535

    • NAID

      10031163212

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin 2/intermedin in the hypothalamo-pituitary-adrenal axis2011

    • Author(s)
      Takahashi K, Morimoto R, Hirose T, Satoh F, Totsune K.
    • Journal Title

      J Mol Neurosci

      Volume: Vol.43 Pages: 182-192

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of (pro) renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women : the Ohasama study2011

    • Author(s)
      Hirose T, Totsune K, et al
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 530-535

    • NAID

      10031163212

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population : the Ohasama study2011

    • Author(s)
      Satoh M, Totsune K, et al
    • Journal Title

      J Hypertens

      Volume: 29 Pages: 1940-1947

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin 2/intermedin in the hypothalamo-pituitary-adrenal axis2011

    • Author(s)
      Takahashi K, Morimoto R, Hirose T, Satoh F, Totsune K
    • Journal Title

      J Mol Neurosci

      Volume: 43 Pages: 182-192

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of kisspeptins and kisspeptin receptor in the kidney of chronic renal failure rats2010

    • Author(s)
      Shoji I, Hirose T, Mori N, Hiraishi K, Kato I, Shibasaki A, Yamamoto H, Ohba K, Kaneko K, Morimoto R, Satoh F, Kohzuki M, Totsune K, Takahashi K.
    • Journal Title

      Peptides

      Volume: Vol.31 Pages: 1920-1925

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of adrenomedullin 2/intermedin, a possible reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure2010

    • Author(s)
      Hirose T, Totsune K, Mori N, Mori T, Morimoto R, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: Vol.299

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of(pro) renin receptor in human kidneys with end-stage kidney disease due to diabetic nephropathy2010

    • Author(s)
      Takahashi K, Yamamoto H, Hirose T, Hiraishi K, Shoji I, Shibasaki A, Kato I, Kaneko K, Sasano H, Satoh F, Totsune K.
    • Journal Title

      Peptides

      Volume: Vol.31 Pages: 1405-1408

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of(pro) renin receptor in the human brain and pituitary, and co-localisation with arginine vasopressin and oxytocin in the hypothalamus2010

    • Author(s)
      Takahashi K, Hiraishi K, Hirose T, Kato I, Yamamoto H, Shoji I, Shibasaki A, Kaneko K, Satoh F, Totsune K.
    • Journal Title

      J Neuroendocrinol

      Volume: Vol.22 Pages: 453-459

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of(pro) renin receptor in the remnant kidneys of 5/6 nephrectomized rats2010

    • Author(s)
      Hirose T, Mori N, Totsune K, Morimoto R, Maejima T, Kawamura T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y.
    • Journal Title

      Regul Pept

      Volume: Vol.159 Pages: 93-99

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Presence of kisspeptin-like immunoreactivity in human adrenal glands and adrenal tumors2010

    • Author(s)
      Takahashi K, Shoji I, Shibasaki A, Kato I, Hiraishi K, Yamamoto H, Kaneko K, Murakami O, Morimoto R, Satoh F, Ito S, Totsune K.
    • Journal Title

      J Mol Neurosci

      Volume: Vol.41 Pages: 138-144

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of (pro)renin receptor in the human brain and pituitary, and co-localisation with arginine vasopressin and oxytocin in the hypothalamus2010

    • Author(s)
      Takahashi K, Hiraishi K, Hirose T, Kato I, Yamamoto H, Shoji I, Shibasaki A, Kaneko K, Satoh F, Totsune K
    • Journal Title

      J Neuroendocrinol

      Volume: 22 Pages: 453-459

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of (pro)renin receptor in human kidneys with end-stage kidney disease due to diabetic nephropathy2010

    • Author(s)
      Takahashi K, Yamamoto H, Hirose T, Hiraishi K, Shoji I, Shibasaki A, Kato I, Kaneko K, Sasano H, Satoh F, Totsune K
    • Journal Title

      Peptides

      Volume: 31 Pages: 1405-1408

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of (pro) renin receptor in the remnant kidneys of 5/6 nephrectomized rats.2010

    • Author(s)
      Hirose T, Mori N, Totsune K, Morimoto R, Maejima T, Kawamura T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y.
    • Journal Title

      Regul Pept. 159

      Pages: 272-277

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression of(pro) renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure2009

    • Author(s)
      Hirose T, Mori N, Totsune K, Morimoto R, Maejima T, Kawamura T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y.
    • Journal Title

      Peptides

      Volume: Vol.30 Pages: 2316-2322

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The renin-angiotensin system, adreno-medullins and urotensin II in the kidney : possible renoprotection via the kidney peptide systems2009

    • Author(s)
      Takahashi K, Hirose T, Mori N, Morimoto R, Kohzuki M, Imai Y, Totsune K.
    • Journal Title

      Peptides

      Volume: Vol.30 Pages: 1575-1585

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of (pro) renin receptor gene polymorphism with blood pressure in Japanese men : the Ohasama study.2009

    • Author(s)
      Hirose T, Hashimoto M, Totsune K, Metoki H, Asayama K, Kikuya M, Sugimoto K, Katsuya T, Ohkubo T, Hashimoto J, Rakugi H, Takahashi K, Imai Y.
    • Journal Title

      Am J Hypertens 22

      Pages: 294-299

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stroke risk of blood pressure indices determined by home blood pressure measurement : the Ohasama study.2009

    • Author(s)
      Inoue R, Ohkubo T, Kikuya M, Metoki H, Asayama K, Kanno A, Obara T, Hirose T, Hara A, Hoshi H, Totsune K, Satoh H, Kondo Y, Imai Y.
    • Journal Title

      Stroke 40

      Pages: 2859-2861

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression of (pro) renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure.2009

    • Author(s)
      Hirose T, Mori N, Totsune K, Morimoto R, Maejima T, Kawamura T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y.
    • Journal Title

      Peptides 30

      Pages: 2316-2322

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Expression of(pro) renin receptor in human erythroid cell lines : the effect of interferon-gamma2011

    • Author(s)
      Kaneko K, Shibasaki A, Nishiyama H, Hirose T, Ohba K, Totsune K, Furuyama K, Takahashi K.
    • Organizer
      53rd American Society of Hematology(ASH) Annual Meeting and Expositio
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2011-12-12
    • Related Report
      2011 Final Research Report
  • [Presentation] (Pro) renin receptor-like immunoreactivity in human plasma2011

    • Author(s)
      Totsune K, Hirose T, Metoki H, Asayama K, Kikuya M, Murakami O, Imai Y, Takahashi K.
    • Organizer
      The American Society of Nephrology(ASN), 44th Annual Meeting
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] (Pro) renin Receptor-Like Immunoreactivity in Patients with Chronic Renal Failure2011

    • Author(s)
      Kazuhito Totsune, 他7名
    • Organizer
      Kidney Week 2011(第44回米国腎臓学会)
    • Place of Presentation
      米国・フィラデルフィア市ペンシルベニアコンベンションセンター
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] アルドステロン産生副腎皮質腺腫と付随副腎における(プロ)レニン受容体の発現2011

    • Author(s)
      山本肇、森本玲、加藤一郎、廣瀬卓男、大場浩史、金子桐子、佐藤文俊、戸恒和人、高橋和広
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2011-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎ネフロンセグメントにおける(プロ)レニン受容体の発現:高食塩水と脱水による調節Expression of(pro) renin receptor in the nephron segments of rat kidney : Regulation by high salt diet and dehydration2011

    • Author(s)
      戎栄、伊藤修、森伸芳、森建史、伊藤貞嘉、戸恒和人、高橋和広、上月正博
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2011-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Prorenin receptor, primary aldosteronism and chronic kidney disease : Possible involvement of adrenal prorenin receptor in chronic kidney disease2011

    • Author(s)
      Takahashi K, Yamamoto H, Kato I, Shibasaki A, Ohba K, Kaneko K, Morimoto R, Murakami O, Satoh F, Hirose T, Totsune K.
    • Organizer
      48th Congress of European Renal Association(ERA)-European Dialysis and Transplant Association
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2011-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 血漿・尿中(プロ)レニン受容体可溶性成分の検討2011

    • Author(s)
      廣瀬卓男、戸恒和人、森信芳、菊谷昌浩、大久保孝義、高橋和広、今井潤
    • Organizer
      第40回日本心脈管作動物質学会
    • Place of Presentation
      高松
    • Year and Date
      2011-02-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Association of (pro)renin receptor gene polymorphism with cardiac hypertrophy, asymptomatic cerebrovascular lesions and chronic kidney disease in Japanese : the Ohasama study2010

    • Author(s)
      Kazuhito Totsune, 他7名
    • Organizer
      Renal Week 2010(第43回米国腎臓学会)
    • Place of Presentation
      米国・デンバー市コロラドコンベンションセンター
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association of(pro) renin receptor gene polymorphism with cardiac hypertrophy, asymptomatic cerebrovascular lesions and chronic kidney disease in Japanese : the Ohasama study2010

    • Author(s)
      Totsune K, Hirose T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Takahashi K, Imai Y.
    • Organizer
      The American Society of Nephrology(ASN), 43rd Annual Meeting
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-09-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Association of adrenomedullin 2 gene I/D polymorphism with cerebral and renal damage in a Japanese general population : the Ohasama study2010

    • Author(s)
      Totsune K, Hirose T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Takahashi K, Imai Y.
    • Organizer
      The American Society of Nephrology(ASN), 43rd Annual Meeting
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-09-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Prorenin receptor in the human brain and pituitary, and its increased expression in the brain of spontaneous hypertensive rats2010

    • Author(s)
      Takahashi K, Hirose T, Hiraishi K, Kato I, Shoji I, Yamamoto H, Shibasaki A, Kaneko K, Mori N, Kohzuki M, Totsune K.
    • Organizer
      The 7th International Congress of Neuroendocrinology
    • Place of Presentation
      Rouen, France
    • Year and Date
      2010-07-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Soluble form of the(Pro) renin receptor in plasma2010

    • Author(s)
      Mori N, Hirose T, Totsune K, Xu B, Rong R, Ito D, Takashima K, Muroya Y, Suzuki F, Nagasaka M, Ebihara S, Ito O, Takahashi K, Imai Y, Kohzuki M.
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Association of adrenomedullin2/intermedin gene insertion/deletion polymorphism with blood pressure, renal function and silent cerebrovascular lesions in a Japanese general population : the Ohasama study2010

    • Author(s)
      Hirose T, Totsune K, Metoki H, Kawamura T, Hara A, Asayama K, Kondo T, Kikuya M, Ohkubo T, Izumi S-I, Takahashi K, Imai Y.
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Prorenin receptor expression in the human kidney and brain2010

    • Author(s)
      Takahashi K, Yamamoto H, Hirose T, Hiraishi K, Shoji I, Shibasaki A, Kato I, Kaneko K, Murakami O, Satoh F, Sasano H, Totsune K.
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Expression of prorenin receptor in the human brain and co-localization with arginine vasopression and oxytocin in the hypothalamus2010

    • Author(s)
      Hiraishi K, Hirose T, Yamamoto H, Shoji I, Shibasaki A, Kato I, Kaneko K, Satoh F, Totsune K, Takahashi K.
    • Organizer
      14th International Congress of Endocrinology(ICE2010)
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2010-03-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Expression of(pro) renin receptor in the nephron segments of rat kidney : regulation by dehydration2010

    • Author(s)
      Rong R, Mori N, Ito O, Muroya Y, Mori T, Ito S, Totsune K, Takahashi K, Kohzuki M.
    • Organizer
      14th International Congress of Endocrinology(ICE2010)
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2010-03-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Renal expression of(Pro) renin receptor is upregulated in rats with chronic renal failure2009

    • Author(s)
      Totsune K, Hirose T, Mori N, Metoki H, Asayama K, Kikuya M, Ohkubo T, Takahashi K, Imai Y.
    • Organizer
      The American Society of Nephrology(ASN), 42nd Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Renal expression of (Pro) renin receptor is upregulated in rats with chronic renal failure.2009

    • Author(s)
      Kazuhito Totsune, 他8名
    • Organizer
      Renal Week 2009(第42回米国腎臓学会)
    • Place of Presentation
      米国・サンディエゴ市
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] アドレノメデュリン2/インターメジン遺伝子多型と無症候性脳血管障害との関連の検討:大迫研究2009

    • Author(s)
      廣瀬卓男、戸恒和人、川村卓也、目時弘仁、星川美奈子、原梓、小原拓、浅山敬、菊谷昌浩、近藤健男、大久保孝義、出江紳一、高橋和広、今井潤
    • Organizer
      第32回日本高血圧学会総会
    • Place of Presentation
      大津
    • Year and Date
      2009-10-02
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi