| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Dysfunction of the glomerular filtration barrier in the kidney causes nephrotic syndrome with massive proteinuria. In the present study, RACK1 was identified as a novel molecule that can interact with actinin 4, an important component for the maintenance of barrier function. Since RACK1 is known to be interact with various signal transduction molecules, the actinin 4/RACK1 interaction is considered to be important for the maintenance of barrier function via the signal transduction system. In addition, novel findings in clinical cases with dysfunction of the glomerular filtration barrier were reported.
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