New approach for the diabetic nephropathy using the inhibition by GSK3

• Project/Area Number: 21591034
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: NAKAYAMA Yushi 熊本大学, 医学部附属病院, 講師 (00363531)
• Co-Investigator(Kenkyū-buntansha): TOMITA Kimio 熊本大学, 大学院・生命科学研究部, 教授 (40114772)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 糖尿病 / 糖尿病性腎症 / GSK-3β / BIO / TGF-β1 / バルプロ酸 / STZ / NRK-52E cells

Research Abstract

Diabetes mellitus was induced by STZ administration to the SD rat. The 2 Z, 3 E-6-bromoindirubin-3-oxime(BIO), a GSK-3 s inhibitor, was administrated peritoneally. In diabetic rat the urinary protein excretion was reduced by BIO administration. The TGF-s1 mRNA expression of glomeruli was suppressed by BIO treatment. It was suggested that the suppression of TGF-s1 by BIO could be involved the amelioration of diabetic nephropathy.

Research Products

• [Journal Article] Aldosterone requires vasopressin V1a receptors on intercalated cells to mediate acid-base homeostasis (2011)
  • Author(s): Izumi, Y., Nakayama, Y, , Tomita, K., et al.
  • Journal Title: J Am Soc Nephrol Volume: 22(4) Pages: 673-680
  • Peer Reviewed
• [Journal Article] Aldosterone requires vasopressin v1a receptors on intercalated cells to mediate Acid-base homeostasis. (2011)
  • Author(s): Izumi, Y., 他
  • Journal Title: J Am Soc Nephrol Volume: 22 Pages: 673-680
  • Peer Reviewed
• [Journal Article] Low pH stimulates vasopressin V2 receptor promoter activity and enhances downregulation induced by V1a receptor stimulation (2009)
  • Author(s): Memetimin, H., Nakayama, Y., Tomita, K., at al.
  • Journal Title: Am J Physiol Renal Physiol Volume: 297(3)
  • Peer Reviewed
• [Journal Article] Vasopressin and hyperosmolality regulate NKCC1 expression in rat OMCD (2009)
  • Author(s): Wakamatsu, S., Nakayama, Y., Tomita, K., et al.
  • Journal Title: Hypertens Res Volume: 32(6) Pages: 481-487
  • NAID: 10024831162
  • Peer Reviewed
• [Journal Article] Acute and chronic metabolic acidosis interferes with aquaporin-2 translocation in the rat kidney collecting ducts (2009)
  • Author(s): Mouri, T., Nakayama, Y., Tomita, K., et al.
  • Journal Title: Hypertens Res Volume: 32(5) Pages: 358-363
  • NAID: 10026122512
  • Peer Reviewed
• [Journal Article] Different mechanisms for the progression of CKD with ACE gene polymorphisms (2009)
  • Author(s): Nakayama, Y., Nonoguchi, H., Tomita, K., et al.
  • Journal Title: Nephron Clin Pract Volume: 111(4)
  • Peer Reviewed
• [Journal Article] A case with acute renal failure and subsequent nephrotic syndrome (2009)
  • Author(s): Nonoguchi, H., Nakayama, Y., Tomita, K., et al.
  • Journal Title: Ren Fail Volume: 31(2) Pages: 162-166
  • Peer Reviewed
• [Journal Article] Different Mechanisms for the Progression of CKD with ACE Gene Polymorphisms (2009)
  • Author(s): Nakayama Y, 他
  • Journal Title: Nephron Clin Pract. 111 Pages: 240-246
  • Peer Reviewed
• [Journal Article] Acute and chronic metabolic acidosis interferes with aquaporin-2 translocation in the rat kidney collecting ducts (2009)
  • Author(s): Mouri T, 他
  • Journal Title: Hypertens Res. 32 Pages: 358-363
  • Peer Reviewed
• [Journal Article] Vasopressin and hyperosmolality regulate NKCC1 expression in rat OMCD. (2009)
  • Author(s): Wakamatsu S, 他
  • Journal Title: Hypertens Res. 32 Pages: 481-488
  • Peer Reviewed
• [Journal Article] Low pH stimulates vasopressin V2 receptor promoter activity and enhances downregulat induced by V1a receptor stimulation (2009)
  • Author(s): Memetimin H, 他
  • Journal Title: Am J Physiol Renal Physiol. 297
  • Peer Reviewed
• [Journal Article] A case with acute renal failure and subsequent nephrotic syndrome (2009)
  • Author(s): Nonoguchi H, 他
  • Journal Title: Ren Fail. 31 Pages: 162-166
  • Peer Reviewed
• [Presentation] QFT陰性のCRP高値透析患者においてINH及びRFPが著効した症例 (2011)
  • Author(s): 中山裕史
  • Organizer: 第43回九州人工透析研究会総会
  • Place of Presentation: かごしま県民交流センター
  • Year and Date: 2011-12-12
• [Presentation] The effect of acetazolamide on the onset of nephropathy in early type 2 diabetes mellitus (2009)
  • Author(s): 中山裕史
  • Organizer: 米国腎臓学会
  • Place of Presentation: 米国(サンディエゴコンベンションセンター)
  • Year and Date: 2009-10-30
• [Book] 腎性貧血の管理について、若手医師のための透析診療のコツ (2011)
  • Author(s): 中山裕史
  • Publisher: 文光堂
• [Book] 腎性貧血の管理について、若手医師のための透析診療のコツ、加藤明彦編集 (2011)
  • Author(s): 中山裕史
  • Total Pages: 225
  • Publisher: 文光堂
• [Book] 慢性腎臓病(CKD)の栄養管理 (2010)
  • Author(s): 中山裕史
  • Publisher: 文光堂
• [Book] 慢性腎臓病(CKD)の栄養管理、加藤明彦監修、市川和子・武政睦子編集 (2010)
  • Author(s): 中山裕史
  • Total Pages: 183
  • Publisher: 文光堂
• [Book] レジデントノート(輸液療法パーフェクト) (2009)
  • Author(s): 中山裕史
  • Publisher: 羊土社
• [Book] レジデントノート(輸液療法パーフェクト) (2009)
  • Author(s): 中山裕史, 冨田公夫
  • Total Pages: 10
  • Publisher: 羊土社
• [Remarks]
  • URL: http://www.kumadai-nephrology.com/
• [Remarks] 熊本大学大学院生命科学研究部腎臓内科学
• [Remarks] 熊本大学医学部附属病院腎臓内科