A comprehensive analysis of serine proteases involved in the renal injury induced by aldosterone and salt loading
| Project/Area Number |
21591035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOMITA Kimio 熊本大学, 大学院・生命科学研究部, 教授 (40114772)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腎臓学 / アルドステロン / セリンプロテアーゼ / 腎障害 / 高血圧 / ナトリウムチャネル / プロスタシン |
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| Research Abstract |
Aldosterone has been demonstrated to induce severe organ damage to animals when administered with high salt diet. We demonstrated that a serine protease inhibitor significantly reduced the progression of renal injury induced by aldosterone and high salt diet, suggesting that serine proteases are involved in the development of renal injury. We isolated plasmin as a candidate serine protease involved in the aldosterone induced renal injury.
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Report
(4 results)
Research Products
(28 results)
