The role of neutral calponin in the relationship between CKD and CVD

• Project/Area Number: 21591041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Showa University
• Principal Investigator: YOSHIMURA Ashio 昭和大学, 医学部, 教授 (50211660)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: CKD / CVD / カルポニン / 線維化 / 慢性腎臓病 / 心・腎連関 / 中性カルポニン / トランスジェニックマウス / 心腎連関 / 心腎相関

Research Abstract

I examined the role of neutral calponin(nCT) in the interstitial injury of both kidneys and heart in old nCT-transgenic mice. for studying the mechanism for cardio-renal association in CKD. Old nCT-Tg mice showed suppression of interstitial inflammation in the kidney and of the development of interstitial fibrosis in both heart and kidneys. Therefore, the induction of nCT may provide a new way to suppress the development of both CKD and CVD23 in old-age CKD patients.

Research Products

• [Presentation] Neutral calponinによる糖尿病の腎組織障害抑制 (2011)
  • Author(s): 乾聖子、吉村吾志夫、他
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-16
• [Presentation] Neutral calponin (calponin-h2, CN2)による糖尿病(DM)の腎組織障害抑制 (2011)
  • Author(s): 乾聖子、吉村吾志夫, 他
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-06-16
• [Presentation] Precedent anti-inflammation and suppression of subsequent interstitial fibrosis in the kidney by non-smooth muscle calponin(calponin-h2) in diabetic mice are independent of both glucose metabolism and expression of its related molecules. (2010)
  • Author(s): K, Inui, T. Nakayama, Y. Inoue, A. Yoshimura
  • Organizer: 米国腎臓学会
  • Place of Presentation: アメリカ(デンバー)
  • Year and Date: 2010-11-29
• [Presentation] Precedent anti-inflammation and suppression of subsequent interstitial fibrosis in the kidney by non-smooth muscle calponin (calponin-h2) in diabetic mice are independent of both glucose metabolism and expression of its related molecules. (2010)
  • Author(s): K.Inui, T.Nakayama, Y.Inoue, A.Yoshimura
  • Organizer: Renal Week 2010 of the American Society of Nephrology
  • Place of Presentation: Colorado (Denver)
  • Year and Date: 2010-11-29
• [Presentation] Non-smooth muscle calponin suppresses active interstitial inflammation and subsequent fibrosis in the kidney after unilateral ureteral obstruction. (2009)
  • Author(s): K. Inui, H. Morita, A. Yoshimura et al
  • Organizer: 米国腎臓学会
  • Place of Presentation: アメリカ(サンディエゴ)
  • Year and Date: 2009-10-31
• [Presentation] Non-smooth muscle calponin suppresses active interstitial inflammation and subsequent fibrosis in the kidney after unilateral ureteral (2009)
  • Author(s): K.Inui, H.Morita, A.Yoshimura, et al
  • Organizer: 米国腎臓学会
  • Place of Presentation: San Diego(USA)
  • Year and Date: 2009-10-31