| Project/Area Number |
21591043
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | St. Marianna University School of Medicine |
|---|
Principal Investigator |
KIMURA Kenjiro 聖マリアンナ医科大学, 医学部, 教授 (00161555)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUGAYA Takeshi 聖マリアンナ医科大学, 医学部, 客員教授 (40381561)
IKEMORI Atsuko 聖マリアンナ医科大学, 医学部, 講師 (80350635)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 間欠的低酸素 / 虚血ストレス / 脂肪酸結合蛋白 / 低酸素 / 高血圧 / 糖尿病 / マウス / 間欠的虚血ストレス / 腎臓 / 糖尿病性腎症 / 尿蛋白 / AKITA糖尿病マウス / 間質尿細管障害 / 尿中アルブミン / 虚血 / 実験動物 |
|---|
| Research Abstract |
Because sleep apnea syndrome(SAS) may contribute to poor control of diabetes or hypertension, it is possible that SAS is a risk factor for the progression of diabetic nephropathy. In this study, genetic models of type 1 diabetes or hypertension model were examined. The mice or rats were housed within a cycled oxygen chamber and were exposed to chronic intermittent hypoxia(CIH) in which oxygen and nitrogen flow rates were adjusted to achieve episodic(10 miniute) reductions of ambient oxygen from 21% to 10% for CIH for 12 hours. Howerver, it was not demonstrated that chronic intermittent hypoxia was related to the deterioration of kidney disease induced by diabetes or hypertension.
|
