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Intermittent hypoxia in the progression of diabetic nephropathy and Intermittent hypoxia in the progression of diabetic nephropathy and Role of fatty acid binding protein

Research Project

Project/Area Number 21591043
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

KIMURA Kenjiro  聖マリアンナ医科大学, 医学部, 教授 (00161555)

Co-Investigator(Kenkyū-buntansha) SUGAYA Takeshi  聖マリアンナ医科大学, 医学部, 客員教授 (40381561)
IKEMORI Atsuko  聖マリアンナ医科大学, 医学部, 講師 (80350635)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords間欠的低酸素 / 虚血ストレス / 脂肪酸結合蛋白 / 低酸素 / 高血圧 / 糖尿病 / マウス / 間欠的虚血ストレス / 腎臓 / 糖尿病性腎症 / 尿蛋白 / AKITA糖尿病マウス / 間質尿細管障害 / 尿中アルブミン / 虚血 / 実験動物
Research Abstract

Because sleep apnea syndrome(SAS) may contribute to poor control of diabetes or hypertension, it is possible that SAS is a risk factor for the progression of diabetic nephropathy. In this study, genetic models of type 1 diabetes or hypertension model were examined. The mice or rats were housed within a cycled oxygen chamber and were exposed to chronic intermittent hypoxia(CIH) in which oxygen and nitrogen flow rates were adjusted to achieve episodic(10 miniute) reductions of ambient oxygen from 21% to 10% for CIH for 12 hours. Howerver, it was not demonstrated that chronic intermittent hypoxia was related to the deterioration of kidney disease induced by diabetes or hypertension.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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