Genetic studies on familial interstitial nephritis
Project/Area Number |
21591045
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Kansai Medical University |
Principal Investigator |
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 尿細管 / ゲノム / 疾患遺伝子 / 慢性腎臓病 / 腎不全 / 間質性腎炎 / 連鎖解析 / 腎尿細管 |
Research Abstract |
Chronic kidney disease(CKD) is clinically heterogeneous groups of diseases at a higher risk of potentially progressing to the end stage renal failure. The CKD is becoming a global health problem since it is indeed highly prevalent at one in eight adult individuals. The tubule-interstitial injuries significantly contribute to the pathogenesis of CKD as a primary initiating factor and/or a secondary exacerbating changes resulting from the glomerular insults. However, earlier tubule-interstitial injuries are often under-recognized because the patients barely manifest overt proteinuria and renal dysfunction. To improve the treatment for CKD, there is a need for elucidation of new disease biomarkers and genetic risk factors underlying tubule-interstitial diseases. This study aimed to identify the disease genes underling a large dominant family with tubule-interstitial nephritis. A combined approach of linkage analysis and next generation sequencing revealed that two novel single nucleotide variants may explain the susceptibility for interstitial nephritis.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney2010
Author(s)
Zhang Y, Yoshida Y, Nameta M, Xu B, Taguchi I, Ikeda T, Fujinaka H, Mohamed SM, Tsukaguchi H, Harita Y, Yaoita E, Yamamoto T
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Journal Title
Nephrol Dial Transplant
Volume: 25
Pages: 1785-1795
Related Report
Peer Reviewed
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[Journal Article] More on clinical renal genetics2010
Author(s)
Grunfeld JP, Hwu W, Chien Y, Brown E, Schlondorff J, Becker Dj, Tsukaguchi H, Uschinski A, Higgs H, Henderson J, Pollak M, et al
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Journal Title
Clin J Am Soc Nephrol
Volume: 5
Pages: 563-567
Related Report
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[Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney.2010
Author(s)
Zhang Y, Yoshida Y, Nameta M, Xu B, Taguchi I, Ikeda T, Fujinaka H, Mohamed SM, Tsukaguchi H, Harita Y, Yaoita E, Yamamoto T.
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Journal Title
Nephrol Dial Transplant.
Volume: 25(6)
Pages: 1785-1795
Related Report
Peer Reviewed
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[Journal Article] More on clinical renal genetics2009
Author(s)
Grunfeld JP, Hwu W, Chien Y, Brown E, Schlondorff J, Becker Dj, Tsukaguchi H, Uschinski A, Higgs H, Henderson J, Pollak M, et al
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Journal Title
Clin J Am Soc Nephrol. 5
Pages: 563-567
Related Report
Peer Reviewed
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[Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normalrat kidney
Author(s)
Zhang Y, Yoshida Y, Nameta M, Xu B, Taguchi I, Ikeda T, Fujinaka H, Mohamed SM, Tsukaguchi H, Harita Y, Yaoita E, Yamamoto T.
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Journal Title
Nephrol Dial Transplant. E pub Jan 12
Related Report
Peer Reviewed
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[Presentation] 家族性IgA腎症の遺伝解析2010
Author(s)
後藤眞, 和田真一, 塚口裕康, 福田陽子, 坂爪実, 辻省次, 成田一衛
Organizer
第53回日本腎臓学会学術集会・総会
Place of Presentation
神戸国際会議場
Year and Date
2010-06-18
Related Report
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