Anti-fibrotic effects of klotho through the inhibition of Wnt signaling

• Project/Area Number: 21591046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kawasaki Medical School
• Principal Investigator: SATOH Minoru 川崎医科大学, 医学部, 講師 (70449891)
• Co-Investigator(Kenkyū-buntansha): KASHIHARA Naoki 川崎医科大学, 医学部, 教授 (10233701) ; MORITA Yoshitaka 川崎医科大学, 医学部, 講師 (50346441)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 腎臓学 / 腎線維化 / 遺伝子改変動物 / マウス / Wnt / 尿細管細胞 / 細胞周期 / G2/M / Klotho / 近位尿細管細胞

Research Abstract

The kidney increases fibrotic changes with aging and gradually progresses to chronic renal failure. The Klotho protein secreted by kidney attenuates fibrosis, progress to renal dysfunction by inhibiting Wnt signal promoting fibrosis. Organ fibrotic changes progresses as well as kidney with aging and leads to organ functional decline with aging. But Klotho may restrain fibrosis of not only the kidney but also the other organs and may work for anti-aging. To keep the renal function normally may lead to the prevention of the aging.

Research Products

• [Journal Article] KlothoとWntシグナリング (2012)
  • Author(s): 佐藤稔、柏原直樹
  • Journal Title: 腎と透析 Volume: 72(3) Pages: 325-329
• [Journal Article] 腎老化とバイオマーカー (2011)
  • Author(s): 佐藤稔、柏原直樹
  • Journal Title: Anti-aging Science Volume: 3(2) Pages: 170-174
• [Journal Article] Overexpression of klotho protein modulates uninephrectomy-induced compensatory renal hypertrophy by suppressing IGF-I signals (2011)
  • Author(s): Nagasu H, Satoh M, Kuwabara A, Yorimitsu D, Kidokoro K, Nishi Y, Tomita N, Sasaki T, Kashihara N
  • Journal Title: Biochemical and biophysical research communications Volume: 407(1) Pages: 39-43
• [Presentation] Mouse renal fibrosis after unilateral ureteral obstruction is reduced by Klotho protein overexpression through Wnt signaling inhibition (2011)
  • Author(s): Satoh M, et al
  • Organizer: American Society of Nephrology Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2011-11-10
• [Presentation] Mouse renal fibrosis after unilateral ureteral obstruction is reduced by Klotho protein overexpression through Wnt signaling inhibition (2011)
  • Author(s): 佐藤稔
  • Organizer: American Society of Nephrology, Kidney Week 2011
  • Place of Presentation: Philadelphia, PA, USA
  • Year and Date: 2011-11-10
• [Presentation] 慢性腎臓病とKlotho-腎性老化仮説- (2010)
  • Author(s): 柏原直樹
  • Organizer: 第40回日本腎臓学会東部学術大会シンポジウム
  • Place of Presentation: 栃木
  • Year and Date: 2010-09-25
• [Presentation] 慢性腎臓病とKlotho-腎性老化仮説- (2010)
  • Author(s): 柏原直樹
  • Organizer: 第40回日本腎臓学会東部学術大会
  • Place of Presentation: 栃木県総合文化センター(栃木県)
  • Year and Date: 2010-09-25
• [Presentation] Klotho過剰発現マウスはWntシグナル抑制により尿管結紮による腎線維化が減弱する (2010)
  • Author(s): 佐藤稔, 他
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] Wnt/beta-catenine/TCFシグナルと腎線維化 (2010)
  • Author(s): 佐藤稔
  • Organizer: 第53回日本腎臓学会学術総会ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] Wnt/beta-catenine/TCFシグナルと腎線維化 (2010)
  • Author(s): 佐藤稔
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-06-17
• [Presentation] Klotho過剰発現マウスはWntシグナル抑制により尿管結紮による腎線維化が減弱する (2010)
  • Author(s): 佐藤稔
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-06-17
• [Presentation] Klotho overexpression attenuates renal fibrosis after unilateral obstruction by Wnt signaling (2010)
  • Author(s): Satoh M, et al
  • Organizer: SN-Nexus Symposium 2010
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-04-17
• [Presentation] Klotho overexpression attenuates renal fibrosis after unilateral obstruction by Wnt signaling inhibition. (2010)
  • Author(s): 佐藤稔
  • Organizer: ISN-Nexus Symposium 2010
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-04-17
• [Presentation] Renal fibrosis after unilateral ureteral obstruction was reduced by over expression of klotho via Wnt signaling inhibition (2010)
  • Author(s): Satoh M, et al
  • Organizer: The 14th Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism
  • Place of Presentation: Nara, Japan
  • Year and Date: 2010-04-01
• [Presentation] Renal fibrosis after unilateral ureteral obstruction was reduced by over expression of klotho via Wnt signaling inhibition. (2010)
  • Author(s): 佐藤稔
  • Organizer: The 14th Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism
  • Place of Presentation: 奈良県新公会堂(奈良県)
  • Year and Date: 2010-04-01
• [Presentation] American Society of Nephrology Kidney Week 2009 (2009)
  • Author(s): Satoh M, et al
  • Organizer: Alpha-klotho attenuates renal fibrosis after unilateral ureteral obstruction through inhibition of Wnt signaling
  • Place of Presentation: San Diego, USA
  • Year and Date: 2009-10-29
• [Presentation] Alpha-klotho attenuates renal fibrosis after unilateral ureteral obstruction through inhibition of Wnt signaling (2009)
  • Author(s): 佐藤稔
  • Organizer: American Society of Nephrology
  • Place of Presentation: SanDiego Convention Center
  • Year and Date: 2009-10-29