| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Albuminuria is strongly associated with cardiovascular diseases. Endothelial dysfunction has been speculated to be involved in the pathogenesis of albuminuria. We have successfully developed a novel in vivo imaging technique which enables us to visualize microcirculation and permeability change in the kidney. Using this technique, we found hyperfiltration of macromolecules precede albuminuria. We also demonstrated endothelial dysfunction, indicated by the loss of glycocalyx along the glomerular vascular wall and uncoupling of eNOS is deeply involved in this condition.
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