| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We selected twenty cases of histologically diagnosed as tubulointerstitial nephritis(TIN). These cases were etiologically different and included four cases of IgG4-related TIN. We extracted RNA from paraffin embedded biopsied kidney, and evaluated expression levels of various cytokines for each case by real time PCR. Comparison of cytokine production patterns among different disease associated TINs revealed that IgG4-related TIN exhibited a quite distinct pattern. On one hand there was no expression of IL-2, IFN-γ, IL-17 and IL-6, whereas productions of IL-4, IL-10 and TGF-β were remarkably increased in IgG4-related TIN. Based on these cytokine production results, Th2 and Treg appears to play a central role in IgG4-related TIN.
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