Elucidation of the interaction between abnormalities of apolipo-protein E and Fc receptors on the development of lipoprotein glomerulopathy.
| Project/Area Number |
21591049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
SAITO Takao 福岡大学, 医学部, 教授 (10125552)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Hitoshi 福岡大学, 医学部, 准教授 (70188960)
SASATOMI Yoshie 福岡大学, 医学部, 講師 (30369003)
ABE Yasuhiro 福岡大学, 医学部, 助教 (50461512)
ITO Kenji 福岡大学, 医学部, 助教 (00580234)
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| Research Collaborator |
WATANABE Maho 福岡大学, 医学部, 大学院研究生
ISHIMURA Atsunori 福岡大学, 医学部, 大学院生
MIYAHARA Yoshito 福岡大学, 医学部, 大学院生
NISHIMURA Shinsuke 福岡大学, 医学部, 大学院研究生
YASUNO Tetsuhiko 福岡大学, 医学部, 助手
FUKUSHIMA Takao 福岡大学, 医学部, 大学院生
IFUKU Masakazu 福岡大学, 医学部, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腎臓学 / 脂質 / 遺伝子 / 応用動物 / 病理学 |
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| Research Abstract |
In FcRγ/apoE-KO mice, human apoE3-injection showed the most drastic changes mimicking lipoprotein glomerulopathy as well as prominent hypertriglyceridemia. These results suggest that the impairment of macrophage function resulting from FcRγdeficiency plays a principal role in the development of LPG in the presence of apoE abnormalities. This may be another aspect of macrophage-induced dyscondition in dyslipidemia.
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Report
(4 results)
Research Products
(22 results)
