| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We initially noticed that the proximal tubule cells at the surface to mid cortex becamevacuolated and apoptotic, whereas those deeper within the cortex proliferatedvigorously and eventually formed cysts. Then by staining kidneys with antibodiesagainst ER-stress-responsive factors, we recognized a strong activation of CHOPexpression in the vacuolated and apoptotic proximal tubule cells. This was evidencethat the apoptosis was the result of ER stress. In contrast to CHOP, GRP78 expressionwas augmented exclusively in the deep-cortex proximal tubule cells, a sign of a similarinduction of ER stress in these cells. Yet in these cells, the ER stress was followed bycellular proliferation.
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