Complement-associated analysis for improvement of prognosis in patients on long-term peritoneal dialysis

• Project/Area Number: 21591054
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: MIZUNO Masashi 名古屋大学, 大学院・医学系研究科, 講座講師 (20303638)
• Co-Investigator(Kenkyū-buntansha): ITO Yasuhiko 名古屋大学, 大学院・医学系研究科, 講座教授 (60402632) ; 松尾 清一 名古屋大学, 大学院・医学系研究科, 教授 (70190410)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 人工透析学 / 腹膜透析 / 慢性腹膜炎症 / 腹膜硬化症 / 補体 / 抗補体治療 / 補体活性化 / 補体制御 / 腹膜障害 / 腹膜透析液

Research Abstract

We showed that membrane complement(C) regulators(CRegs) played key roles in normal rat peritoneum and that low pH and high osmotic pressure as elements of peritoneal dialysis(PD) fluid increased peritoneal injuries under functional blocking of CRegs. We also showed that CRegs' impairments might accelerate peritoneal injuries to encapsulating peritoneal sclerosis in the zymosan induced peritonitis model in rats.

Research Products

• [Journal Article] Me mbrane complement regulators protect against fibrin-exudation, an early stage of encapsulating peritoneal sclerosis(EPS) (2012)
  • Author(s): Mizuno M, Ito Y, Mizuno T, Suzuki Y, Harris CL, Okada N, Matsuo S, Morgan BP.
  • Journal Title: Am J Physiol Renal Physiol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Transforming growth factor-υin duce vascular endo the lial growth factor-C expressio nleading to lymph angiogenesis in rat unilateral ureteral obstruction. (2012)
  • Author(s): Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, Mizuno T, Shimizu H, Fujita Y, Matsui K, Maruyama S, Imai E, Matsuo S, Takei Y.
  • Journal Title: Kidney Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] Low serum cultured a dipose tissue-derived stromal cells a meliorate acute kidney injury in rats (2012)
  • Author(s): Katsuno T, Osaki T, Saka Y, Furuhashi K, Kim H, Yasuda K, Yamamoto T, Sato W, Tsuboi N, Mizuno M, Ito Y, Imai E, Matsuo S, Maruyama S.
  • Journal Title: Cell Transplant Volume: (in press)
  • Peer Reviewed
• [Journal Article] Asympto maticdiver ticulosis identified by computed tomography is not a risk factor for enteric peritonitis (2012)
  • Author(s): Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.
  • Journal Title: Nephrol Dial Tranplant Volume: (in press)
  • Peer Reviewed
• [Journal Article] Atrial natriuretic peptide ameliorates peritoneal fibrosis in a rat peritonitis model (2012)
  • Author(s): Kato H, Mizuno T, Mizuno M, Sawai A, Suzuki Y, Kinashi H, Nagura F, Maruyama S, Noda Y, Yamada K, Matsuo S, Ito Y.
  • Journal Title: Nephrol. Dial. Transplant Volume: 27 Pages: 526-536
  • Peer Reviewed
• [Journal Article] Aliskiren-induced chyloperotoneum in a patient on peritoneal dialysis (2012)
  • Author(s): Saka Y, Tachi H, Sakurai H, Tawada M, Sawai A, Shimamura Y, Mizuno M, Maruyama S, Matsuo S, Ito Y.
  • Journal Title: Perit Dial Int Volume: 32 Pages: 111-113
  • Peer Reviewed
• [Journal Article] Renal impairment after laparoscopic radical nephrectomy affects hypoglycemic therapy (2012)
  • Author(s): Mizuno T, Ito K, Miyagawa Y, Kimura K, Suzuki K, Mizuno M, Ito Y, Funabashi Y, Hattori R, Gotoh M, Noda Y, Yamada K.
  • Journal Title: J. Clin Pharm Therapy Volume: 37 Pages: 49-52
  • Peer Reviewed
• [Journal Article] Aliskiren-induced chyloperotoneum in a patient on peritoneal dialysis (2012)
  • Author(s): Saka Y, Tachi H, Sakurai H, Tawada M, Sawai A, Shimamura Y, Mizuno M, Maruyama S, Matsuo S, Ito Y
  • Journal Title: Pent Dial Int Volume: Vol.32 Pages: 111-112
  • Peer Reviewed
• [Journal Article] Atrial natriuretic peptide ameliorates peritoneal fibrosis in a rat peritonitis model (2012)
  • Author(s): Kato H, Mizuno T, Mizuno M, Sawai A, Suzuki Y, Kinashi H, Nagura F, Maruyama S, Noda Y, Yamada K, Matsuo S, Ito Y
  • Journal Title: Nephrol.Dial.Transplant. Volume: Vol.27 Issue: 2 Pages: 526-536
  • DOI: 10.1093/ndt/gfr302
  • Peer Reviewed
• [Journal Article] Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction (2012)
  • Author(s): Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, Mizuno T, Shimizu H, Fujita Y, Matsui K, Maruyama S, Imai E, Matsuo S, Takei Y
  • Journal Title: Kidney Int. Volume: (印刷中)(未定) Issue: 9 Pages: 865-79
  • DOI: 10.1038/ki.2011.464
  • Peer Reviewed
• [Journal Article] Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats (2012)
  • Author(s): Katsuno T, Osaki T, Saka Y, Furuhashi K, Kim H, Yasuda K, Yamamoto T, Sato W, Tsuboi N, Mizuno M, Ito Y, Imai E, Matsuo S, Maruyama S
  • Journal Title: Cell Transplant. Volume: (印刷中)(未定)
  • Peer Reviewed
• [Journal Article] Membrane complement regulators protect against fibrin-exudation, an early stage of encapsulating peritoneal sclerosis (EPS), in a chronic proliferative peritoneal inflammation model in the rat (2012)
  • Author(s): Mizuno M, Ito Y, Mizuno T, Suzuki Y, Harris CL, Okada N, Matsuo S, Morgan BP
  • Journal Title: Am.J.Physil.Renal Physiol. Volume: (印刷中)(未定)
  • Peer Reviewed
• [Journal Article] Peritonitis is still an important factor for withdrawal from peritoneal dialysis the rapy in the Tokai area of Japan (2011)
  • Author(s): Mizuno M, Ito Y, Tanaka A, Suzuki Y, Hiramatsu H, Watanabe M, Tsuruta Y, MatsuokaT, Ito I, Tamai H, Kasuga H, Shimizu H, Kurata H, Inaguma D, Hiramatsu T, Horie M, Naruse T, Maruyama S, Imai E, Yuzawa Y, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: 15 Pages: 727-737
  • Peer Reviewed
• [Journal Article] A case of perforative peritonitis by a piece of bamboo in a patient on peritoneal dialysis (2011)
  • Author(s): Suzuki Y, Mizuno M, Nakashima R, Hiramatsu H, Toda S, Sato W, Tsuboi N, Ito I, Maruyama S, Imai E, Matsuo S, Ito Y.
  • Journal Title: Clin Exp Nephrol Volume: 15 Pages: 962-965
  • Peer Reviewed
• [Journal Article] A case of fulminant peritonitis caused by Streptococcus mitis in a patient on peritoneal dialysis (2011)
  • Author(s): Mizuno M, Ito Y, Masuda T, Toda S, Hiramatsu H, Suzuki Y, Ozaki T, Yasuda Y, Ito I, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.
  • Journal Title: Intern Med Volume: 50 Pages: 471-474
  • NAID: 130000649863
  • Peer Reviewed
• [Journal Article] A case of acute renal failure caused by cholesterol embolization after carotid artery tenting that was improved by peritoneal dialysis (2011)
  • Author(s): Mizuno M, Ito Y, Hayasaki T, Suzuki Y, Hiramatsu H, Toda S, Tatematsu M, Ozaki T, Sato W, Tsuboi N, Ito I, Marumaya S, Imai E, Matsuo S.
  • Journal Title: Intern Med Volume: 50 Pages: 1719-1723
  • Peer Reviewed
• [Journal Article] An update on the roles of the complement system in autoimmune diseases and the therapeutic possibilities of anti-complement agents (2011)
  • Author(s): Mizuno M, Morgan BP.
  • Journal Title: Current Drug Therapy Volume: 6 Pages: 35-50
  • Peer Reviewed
• [Journal Article] Specific collaboration between rat membrane complement regulators Crry and CD 59 protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid (2011)
  • Author(s): Mizuno T, Mizuno M, Okada N, Morgan BP, Noda Y, Yamada K, Okada N, Yuzawa Y, Matsuo S, Ito Y.
  • Journal Title: Nephrol. Dial. Transplant Volume: 26 Pages: 1821-1830
  • Peer Reviewed
• [Journal Article] Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients (2011)
  • Author(s): Sawai A, Ito Y, Mizuno M, Toda S, Ito I, Hattori R, Matsukawa Y, Gotoh M, Takei Y, Yuzawa Y, Matsuo S.
  • Journal Title: Nephrol. Dial. Transplant Volume: 26 Pages: 2322-2332
  • Peer Reviewed
• [Journal Article] 腹膜透析にかかわる腹膜組織障害における補体の関与 (2011)
  • Author(s): 水野正司、伊藤恭彦、松尾清一
  • Journal Title: 医学のあゆみ Volume: Vol.239 Pages: 779-783
  • Peer Reviewed
• [Journal Article] 残腎機能を有する腹膜透析患者に対するシナカルセト投与時のMg、K代謝に及ぼす影響 (2011)
  • Author(s): 柴田佳菜子、伊藤恭彦、水野正司、鈴木康弘、平松英樹、伊藤功、戸田晋、丸山彰一、松尾清一
  • Journal Title: 日本透析医学会雑誌 Volume: Vol.44 Pages: 1007-1013
  • NAID: 10029861706
  • Peer Reviewed
• [Journal Article] Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid (2011)
  • Author(s): Mizuno T, Mizuno M, Okada N, Morgan BP, Noda Y, Yamada K, Okada N, Yuzawa Y, Matsuo S, Ito Y
  • Journal Title: Nephrol.Dial.Transplant. Volume: Vol.26 Issue: 6 Pages: 1821-1830
  • DOI: 10.1093/ndt/gfq683
  • Peer Reviewed
• [Journal Article] Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients (2011)
  • Author(s): Sawai A, Ito Y, Mizuno M, Toda S, Ito I, Hattori R, Matsukawa Y, Gotoh M, Takei Y, Yuzawa Y, Matsuo S
  • Journal Title: Nephrol.Dial.Transplant. Volume: Vol.26 Issue: 1 Pages: 2322-2332
  • DOI: 10.3747/pdi.2011.00049
  • Peer Reviewed
• [Journal Article] A Case of Fulminant Peritonitis Caused by Streptococcus mitis in a Patient on Peritoneal Dialysis (2011)
  • Author(s): Mizuno M, Ito Y, Masuda T, Toda S, Hiramatsu H, Suzuki Y, Ozaki T, Yasuda Y, Ito I, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S
  • Journal Title: Internal Medicine Volume: 50 Issue: 5 Pages: 471-474
  • DOI: 10.2169/internalmedicine.50.4122
  • NAID: 130000649863
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] A Case of Acute Renal Failure Caused by Cholesterol Embolization after Carotid Artery Stenting that was Improved by Peritoneal Dialysis (2011)
  • Author(s): Mizuno M, Ito Y, Hayasaki T, Suzuki Y, Hiramatsu H, Toda S, Tatematsu M, Ozaki T, Sato W, Tsuboi N, Ito I, Marumaya S, Imai E, Matsuo S
  • Journal Title: Internal Medicine Volume: 50 Issue: 16 Pages: 1719-1723
  • DOI: 10.2169/internalmedicine.50.5358
  • NAID: 130000969375
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan (2011)
  • Author(s): Mizuno M, Ito Y, Tanaka A, Suzuki Y, Hiramatsu H, Watanabe M, Tsuruta Y, Matsuoka T, Ito I, Tamai H, Kasuga H, Shimizu H, Kurata H, Inaguma D, Hiramatsu T, Horie M, Naruse T, Maruyama S, Imai E, Yuzawa Y, Matsuo S
  • Journal Title: Clin.Exp.Nephrol. Volume: Vol.15 Issue: 5 Pages: 727-737
  • DOI: 10.1007/s10157-011-0471-8
  • NAID: 10030341127
  • Peer Reviewed
• [Journal Article] A case of perforative peritonitis by a piece of bamboo in a patient on peritoneal dialysis (2011)
  • Author(s): Suzuki Y, Mizuno M, Nakashima R, Hiramatsu H, Toda S, Sato W, Tsuboi N, Ito I, Maruyama S, Imai E, Matsuo S, Ito Y
  • Journal Title: Clin.Exp.Nephrol. Volume: Vol.15 Issue: 6 Pages: 962-965
  • DOI: 10.1007/s10157-011-0529-7
  • Peer Reviewed
• [Journal Article] Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis (2011)
  • Author(s): Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S
  • Journal Title: Nephrol.Dial.Tranplant. Volume: 27(6) Issue: 6 Pages: 2511-6
  • DOI: 10.1093/ndt/gfr685
  • Peer Reviewed
• [Journal Article] A case of fulminant peritonitis caused by Streptococcus nitis in a patient on peritoneal diaiysis. (2011)
  • Author(s): Mizuno M., Ito Y., I., Masuda T, T oda S., Hiramatsu H., Suzuki Y., Ozaki T, Yasuda Y., ItO I., Tsuboi N., Sato W., Maruyama S,, Imai E., Matsuo S.
  • Journal Title: Internal Medicine Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Connecting tissue growth factor(CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate (2010)
  • Author(s): Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, Matsukawa Y, Imai M, Oliver N, Goldshmeding R, Aten J, Krediet R, Yuzawa Y, Matsuo S.
  • Journal Title: Am. J. Physiol. Renal Physiol Volume: 298
  • Peer Reviewed
• [Journal Article] Pathological changes in chronic eosinophilic peritonitis in peritoneal dialysis patient (2010)
  • Author(s): Yuzawa Y, Ito Y, Mizuno M, Sawai A, Matsuo S.
  • Journal Title: Nephrol Dial. Transplant. Plus Volume: 3 Pages: 372-375
  • Peer Reviewed
• [Journal Article] Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia (2010)
  • Author(s): Yuzawa Y, Sato W, Masuda T, Hamada Y, Tatematsu M, Yasuda Y, Ozaki T, Ito I, Mizuno M, Maruyama S, Ito Y, Matsuo S.
  • Journal Title: Inter Med Volume: 49 Pages: 1139-1142
  • NAID: 130000251642
  • Peer Reviewed
• [Journal Article] IX.免疫学的検査C.補体および関連物質 (2010)
  • Author(s): 水野正司、松尾清一
  • Journal Title: 日本臨床 Volume: Vol.68 Pages: 49-52
  • Peer Reviewed
• [Journal Article] 名大腎不全システム研究会レジストリによる東海地区13施設の3年間(2005～2007)解析から得た、現在の腹膜透析療法の傾向と問題点 (2010)
  • Author(s): 水野正司、伊藤恭彦、田中章郎、平松英樹、渡辺緑子、稲熊大城、戸田晋、檀原敦、玉井宏史、倉田久嗣、春日弘毅、志水英明、松岡哲平、鶴田吉和、堀江正宣、成瀬友彦、平松武幸、伊藤功、丸山彰一、湯澤由紀夫、松尾清一
  • Journal Title: 腎と透析2010 Volume: Vol.69 Pages: 638-640
  • Peer Reviewed
• [Journal Article] 基礎カンファレンス腹膜線維化に関する基礎研究の進歩、腹膜線維症・機能不全と成長因子 (2010)
  • Author(s): 伊藤恭彦、水野正司、水谷真、西村勇人、鈴木康弘、澤井晶穂、鬼無洋、湯澤由紀夫、松尾清一
  • Journal Title: 腎と透析2010 Volume: Vol.69 Pages: 128-131
  • Peer Reviewed
• [Journal Article] Connecting tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate. (2010)
  • Author(s): Mizutani M., Ito Y., Mizuno M., Nishimura H., Suzuki Y., Hattori R., Matsukawa Y, Imai M, Oliver N., Goldshmeding R., Aten J., Krediet R, Yuzawa Y., Matsuo S.
  • Journal Title: American Journal of Physiology Renal Physiology Volume: Vol.298
  • Peer Reviewed
• [Journal Article] Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia. (2010)
  • Author(s): Yuzawa Y, Sato W., Masuda T., Hamada Y., Tatematsu M., Yasuda Y., Ozaki T., Ito I., Mizuno M., Maruyama S., Ito Y., Matsuo S.
  • Journal Title: Internal Medicine Volume: Vol.49 Pages: 1139-1142
  • NAID: 130000251642
  • Peer Reviewed
• [Journal Article] Pathological changes in chronic eosinophilic peritonitis in peritoneal dialysis patient. (2010)
  • Author(s): Yuzawa Y., Ito Y., Mizuno M., Sawai A., Matsuo S.
  • Journal Title: Nephrol.Dial.Transplant.Plus Volume: Vol.3 Pages: 372-375
  • Peer Reviewed
• [Journal Article] An update on the roles of the complement system in autoimmune diseases and the therapeutic possibilities of anti-complement agents. (2010)
  • Author(s): Mizuno M., Morgan BP.
  • Journal Title: Current Drug Therapy Volume: Vol.6 Pages: 35-50
  • Peer Reviewed
• [Journal Article] Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid. (2010)
  • Author(s): Mizuno T., Mizuno M., Okada N., Morgan BP., Noda Y., Yamada K., Okada N., Yuzawa Y., Matsuo S., Ito Y.
  • Journal Title: Nephrol.Dial.Transplant Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Peritoneal macrophage infiltration is correlated with baseline peritoneal solute tran sport rate in peritoneal dialysis patients. (2010)
  • Author(s): Sawai A., Ito Y., Mizuno M., Toda S., Ito I., Hattori R., Matsukawa Y., Gotoh M., Takei Y, Yuzawa Y., Matsuo S.
  • Journal Title: Nephrol.Dial.Transplant Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Lymphatic vessels develop during tubulo-interstitial fibrosis (2009)
  • Author(s): Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.
  • Journal Title: Kidney Int Volume: 75 Pages: 828-838
  • Peer Reviewed
• [Journal Article] Zymosan, but not LPS, developed severe and progressive peritoneal injuries accompanied with complement activation in peritoneal dialysate fluid in a rat peritonitis model with mechanical scraping (2009)
  • Author(s): Mizuno M, Ito Y, Mizuno T, Harris CL, Morgan BP, Hepburn N, Noda Y, Yuzawa Y, Matsuo S.
  • Journal Title: J. Immunol Volume: 183 Pages: 1403-1412
  • Peer Reviewed
• [Journal Article] Tissue-type plasmiogen activator deficiency attenuates peritoneal fibrosis in mice (2009)
  • Author(s): Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.
  • Journal Title: Am. J. Physiol. Renal Physiol Volume: 297
  • Peer Reviewed
• [Journal Article] Lymphatic vessels develop during tubulo-interstitial fibrosis. (2009)
  • Author(s): Sakamoto I., et al.
  • Journal Title: Kidney International Vol. 75 Pages: 828-838
  • Peer Reviewed
• [Journal Article] Zymosan, but not LPS, developed severe and progressive peritoneal injuries accompanied with complement activation in peritoneal dialysate fluid in a rat peritonitis model with mechanical scraping. (2009)
  • Author(s): Mizuno M., et al.
  • Journal Title: Journal of Immunology Vol. 183 Pages: 1403-1412
  • Peer Reviewed
• [Journal Article] Tissue-type plasmiogen activator deficiency attenuates peritoneal fibros is in mice. (2009)
  • Author(s): Kurata K., et al.
  • Journal Title: American Journal of Physiology Renal Physiology Vol. 297
  • Peer Reviewed
• [Journal Article] Connecting tissue growth factor(CTGF/CCN2)is increased in peritoneal dialysis patients with high peritoneal solute transport rate. (2009)
  • Author(s): Mizutani M., et al.
  • Journal Title: American Journal of Physiology Renal Physiology 298(3)
  • Peer Reviewed
• [Presentation] Evaluation of diverticular diseases by computed tomography is useful for selection of peritoneal dialysis modality and asymptomatic diverticulosis is not a risk factor for peritonitis (2011)
  • Author(s): Ito Y, Toda S, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Sato W, Tsuboi N, Maruyama S, Imai E, Matsuo S
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2011-11-12
• [Presentation] Lymphangiogenesis develops during peritoneal fibrosis in peritoneal dialysis patients and rat peritonitis model (2011)
  • Author(s): Kinashi H, Ito Y, Mizuno M, Suzuki Y, Nagura F, Sato W, Tsuboi N, Maruyama S, Imai E, Takei Y, Matsuo S
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2011-11-11
• [Presentation] Association of cardiac valve calcification and C-reactive protein (CRP) with cardiovascular and all-cause mortality in end-stage renal disease patients-10-year follow-up study from induction of hemodialysis therapy (2011)
  • Author(s): Ito Y, Kasuga H, Mizuno M, Kimura K, Maruyama S, Imai E, Matsuo S
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2011-11-11
• [Presentation] Low serum cultured adipose derived stem cells ameliorate zymosan induced severe rat peritonitis model (2011)
  • Author(s): Kim H, Mizuno M, Furuhashi K, Katsuno T, Yasuda K, Ozaki T, Sato W, Tsuboi N, Ito Y, Imai E, Maruyama S, Matsuo S
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2011-11-10
• [Presentation] ワークショップ6腹膜劣化予防の決め手はこれだ!腹膜組織における補体活性化の観点から見た、現在の透析液の問題 (2011)
  • Author(s): 水野正司、伊藤恭彦、鈴木康弘、松尾清一
  • Organizer: 第17回日本腹膜透析医学会学術集会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2011-09-25
• [Presentation] 腹膜透析における小・中・大分子量物質除去と腹膜機能の関連性 (2011)
  • Author(s): 平松英樹、伊藤恭彦、水野正司、鈴木康弘、戸田晋、坪井直毅、伊藤功、佐藤和一、丸山彰一、今井圓裕、林裕樹、松尾清一
  • Organizer: 第17回日本腹膜透析医学会学術集会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2011-09-24
• [Presentation] 腹膜透析によって発現する腹膜線維症に対するカルペリチドの予防効果の検討 (2011)
  • Author(s): 水野智博、水野正司、鈴木康弘、澤井晶穂、鬼無洋、名倉史子、寺林武、清裕美、丸山彰一、松尾清一、伊藤恭彦
  • Organizer: 第17回日本腹膜透析医学会学術集会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2011-09-24
• [Presentation] 腹膜透析に関わる組織障害への補体関与の解析と、腹膜障害に対する抗補体療法の可能性 (2011)
  • Author(s): 水野正司
  • Organizer: 第48回補体シンポジウム
  • Place of Presentation: 名古屋市立大学医学部(愛知県)
  • Year and Date: 2011-09-03
• [Presentation] 急性腹膜傷害に対するC5aの関与とC5a阻害薬の有用性 (2011)
  • Author(s): 水野智博、水野正司、櫛田真由、野田幸裕、山田清文、今井優樹、岡田則子、岡田秀親、丸山彰一、松尾清一、伊藤恭彦
  • Organizer: 第48回補体シンポジウム
  • Place of Presentation: 名古屋市立大学医学部(愛知県)
  • Year and Date: 2011-09-02
• [Presentation] 腹膜擦過にZymosan投与により誘導される高度のラット腹膜炎症モデルにおける、低血清培養による脂肪間葉系幹細胞(LASC)の有用性 (2011)
  • Author(s): 金恒秀、水野正司、伊藤恭彦、野田幸裕、山田清文、今井優樹、岡田則子、伊藤恭彦、松尾清一、丸山彰一
  • Organizer: 第48回補体シンポジウム
  • Place of Presentation: 名古屋市立大学医学部(愛知県)
  • Year and Date: 2011-09-02
• [Presentation] Non-physiological osmolarity and pH in peritoneal dialysis fluid impair complement regulation in rat peritoneal mesothelial cells (2011)
  • Author(s): Mizuno M, Mizuno T, Ito Y, Suzuki Y, Kinashi H, Noda Y, Yamada K, Okada N, Morgan BP, Matsuo S
  • Organizer: 13^<th> European Complement in Human disease
  • Place of Presentation: Netherland, Leiden
  • Year and Date: 2011-08-22
• [Presentation] 多肢趾壊死を伴ったコレステロール塞栓症による腎不全に対して腹膜透析を選択した一例 (2011)
  • Author(s): 早崎貴洋、中島涼子、野中慶佑、立松美穂、戸田晋、鈴木康弘、尾崎武徳、小杉智紀、安田宜成、佐藤和一、坪井直毅、伊藤功、水野正司、今井圓裕、丸山彰一、伊藤恭彦、松尾清一
  • Organizer: 第56回日本透析医学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-06-18
• [Presentation] ラット腹膜における膜補体制御因子の役割と腹膜透析の与える影響 (2011)
  • Author(s): 水野智博、水野正司、鈴木康弘、野田幸祐、山田清文、松尾清一、伊藤恭彦
  • Organizer: 第56回日本透析医学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-06-17
• [Presentation] Oxaliplatinにより自己免疫性溶血性貧血・血小板減少を伴うAKIを来した一例 (2011)
  • Author(s): 伊藤功、早川貴洋、中島涼子、野中慶佑、立松美穂、鈴木康弘、戸田晋、尾崎武徳、小杉智紀、安田宜成、佐藤和一、坪井直毅、水野正司、丸山彰一、伊藤恭彦、今井圓裕、松尾清一
  • Organizer: 第56回日本透析医学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-06-17
• [Presentation] 疣贅PCRによりStaphylococcus warneriを起因菌と同定できた感染性心内膜炎の一例 (2011)
  • Author(s): 伊藤功、早川貴洋、中島涼子、野中慶佑、立松美穂、鈴木康弘、戸田晋、尾崎武徳、小杉智紀、安田宜成、佐藤和一、坪井直毅、水野正司、丸山彰一、伊藤恭彦、今井圓裕、松尾清一
  • Organizer: 第56回日本透析医学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-06-17
• [Presentation] Zymosanによる高度炎症の腹膜炎モデルに対する低血清培養脂肪由来間葉系幹細胞(LASC)の効果 (2011)
  • Author(s): 金恒秀、水野正司、清水明日香、阿部智子、古橋和拡、勝野敬之、尾崎武徳、坪井直毅、今井圓裕、伊藤恭彦、松尾清一、丸山彰一
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-06-17
• [Presentation] Low Serum Cultured Adipose Derived Stem Cells Ameliorate Zymosan Induced Severe Rat Perito nitis Model (2011)
  • Author(s): Kim H, Mizuno M, et al.
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
• [Presentation] Lymph angiogenesis Developsduring Peritoneal Fibrosis in Peritoneal Dialysis Patients and Rat Peritonitis Model (2011)
  • Author(s): Kinashi H, et al.
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
• [Presentation] Association of Cardiac Valve Calcification and C-Reactive Protein(CRP) with Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients (2011)
  • Author(s): Ito Y, et al.
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
• [Presentation] Evaluation of Diverticular Diseases by Computed Tomography Is Useful for Selection of Peritoneal Dialysis Modality and Asympto matic Diverticulosis Is Not a Risk Factor for Peritonitis (2011)
  • Author(s): Ito Y, et al.
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
• [Presentation] 腹膜透析に関わる組織障害への補体関与の解析と、腹膜障害に対する抗補体療法の可能性 (2011)
  • Author(s): 水野正司
  • Organizer: 第48回補体シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] 腹膜擦過にZymosan投与により誘導される高度のラット腹膜炎症モデルにおける、低血清培養による脂肪間葉系幹細胞(LASC)の有用性 (2011)
  • Author(s): 金恒秀、水野正司, 他
  • Organizer: 第48回補体シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] Non-phy siologicalo smolarity and pH in peritoneal dialysis fluid impair comple ment regulation in rat peritoneal mesothelial cells (2011)
  • Author(s): Mizuno M, et al.
  • Organizer: 13^<th> European Complement in Human disease
  • Place of Presentation: Leiden, Holland
• [Presentation] ラット腹膜における膜補体制御因子の役割と腹膜透析の与える影響 (2011)
  • Author(s): 水野智博、水野正司, 他
  • Organizer: 第56回日本透析医学会総会
  • Place of Presentation: 横浜
• [Presentation] Zymosan triggers severe and long-term peritoneal injury accompanied by complement activation in a rat peritonitis modelby physical scraping (2011)
  • Author(s): Mizuno M, et al.
  • Organizer: 7^<th> International congress on uremia research and toxicity
  • Place of Presentation: Nagoya, Japan
• [Presentation] Peritoneal macrophage in filtration is the predictor of baseline peritonealsolute transport rate in peritoneal dialysis(PD) patients (2011)
  • Author(s): Ito Y, et al.
  • Organizer: 7^<th> International congress on uremia research and toxicity
  • Place of Presentation: Nagoya, Japan
• [Presentation] Lymphangiogenesis Developsduring Tubulo-lnterstitial Fibrosis Via theTGF-B-VEGF-C Pathway in Rat UnilateralUreteral Obstruction (2011)
  • Author(s): Suzuki Y, et al.
  • Organizer: ASN Renal Week 2010
  • Place of Presentation: Denver, USA
• [Presentation] Zymosan triggers severe and long-term peritoneal injury accompanied by complement activation in a rat peritonitis model by physical scraping (2011)
  • Author(s): Mizuno M, Ito Y, Mizuno T, Suzuki Y, Kinashi H, Imai E, Maruyama S, Harris CL, Morgan BP, Matsuo S
  • Organizer: 7^<th> International congress on uremia research and toxicity
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Peritoneal macrophage infiltration is the predictor of baseline peritoneal solute transport rate in peritoneal dialysis (PD) patients (2011)
  • Author(s): Ito Y, Sawai, A, Mizuno M, Suzuki Y, Toda S, Ito I, Sato W, Imai E, Maruyama S, Matsuo S
  • Organizer: 7^<th> International congress on uremia research and toxicity
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] 血液透析(HD)・腹膜透析(CAPD)患者の酸塩基平衡 (2011)
  • Author(s): 鶴田吉和、木戸聡子、池田一則、田中章郎、水野正司、伊藤恭彦
  • Organizer: 第56回日本透析医学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 竹片様異物によるS状結腸穿孔により発症したCAPD腹膜炎の一例 (2011)
  • Author(s): 鈴木康弘、野中慶佑、戸田晋、安田香、尾崎武徳、小杉智規、佐藤和一、坪井直毅、伊藤功、水野正司、丸山彰一、今井圓裕、伊藤恭彦、松尾清一
  • Organizer: 第17回日本腹膜透析医学会学術集会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
• [Presentation] Zymosanによる増殖性腹膜炎モデルの作成と補体の関与 (2010)
  • Author(s): 水野正司、伊藤恭彦、鈴木康弘、水野智博、名倉史子、鬼無洋、澤井晶穂、野田幸裕、山田清文、丸山彰一、松尾清一
  • Organizer: 第16回日本腹膜透析学会・総会
  • Place of Presentation: Iichiko総合文化センター・大分全日光ホテルオアシスタワー(大分県)
  • Year and Date: 2010-11-07
• [Presentation] 正常ラット腹膜における膜補体制御因子の機能的役割と腹膜透析液暴露による補体活性系への影響 (2010)
  • Author(s): 水野智博、水野正司、伊藤恭彦、鈴木康弘、澤井昌穂、鬼無洋、野田幸裕、山田清文、丸山彰一、松尾清一
  • Organizer: 第16回日本腹膜透析学会・総会
  • Place of Presentation: Iichiko総合文化センター・大分全日光ホテルオアシスタワー(大分県)
  • Year and Date: 2010-11-07
• [Presentation] 正常ラット腹膜における膜補体制御因子の機能的役割 (2010)
  • Author(s): 水野智博、水野正司、伊藤恭彦、鈴木康弘、野田幸裕、山田清文、丸山彰一、岡田紀則子、B.Paul Morgan、松尾清一
  • Organizer: 第47回補体シンポジウム
  • Place of Presentation: コラッセ福島(福島県)
  • Year and Date: 2010-09-11
• [Presentation] Thrombotic microangiopathyと補体(シンポジウム:腎疾患と補体) (2010)
  • Author(s): 水野正司
  • Organizer: 第47回補体シンポジウム
  • Place of Presentation: コラッセ福島(福島県)
  • Year and Date: 2010-09-11
• [Presentation] Membrane complement regulators may protect against encapsuiar peritoneal sclerosis (EPS) in a chronic proliferative inflammation model of zymosan peritonitis in the rat. (2010)
  • Author(s): Mizuno M., Ito Y., Mizuno T., Suzuki Y, Noda Y., Yamada K., Harris CL., Okada N., Morgan BP., Matsuo S.
  • Organizer: XXII International complement workshop
  • Place of Presentation: New York, USA
  • Year and Date: 2010-08-02
• [Presentation] Zymosan(Z)による増殖性腹膜炎モデルの作成と補体治療の可能性 (2010)
  • Author(s): 水野正司、伊藤恭彦、Morgan B Paul、湯澤由紀夫、松尾清一
  • Organizer: 第55回日透析医学会学術集会・総会
  • Place of Presentation: 神戸コンベンションセンター・神戸ポートピアホテル(兵庫県)
  • Year and Date: 2010-06-18
• [Presentation] Pertoneal Ma crophage lnfiltration Is Correlated with Baseline Peritoneal Solute Transport Rare Peritoneal Dialysis Patients (2010)
  • Author(s): Sawai A, et al.
  • Organizer: ASN Renal Week 2010
  • Place of Presentation: Denver, USA
• [Presentation] 正常ラット腹膜における膜補体制御因子の機能的役割と腹膜透析液暴露による補体活性系への影響 (2010)
  • Author(s): 水野智博、水野正司, 他
  • Organizer: 第16回日本腹膜透析学会・総会
  • Place of Presentation: 大分
• [Presentation] Zymosanによる増殖性腹膜炎モデルの作成と補体の関与 (2010)
  • Author(s): 水野正司, 他
  • Organizer: 第16回日本腹膜透析学会・総会
  • Place of Presentation: 大分
• [Presentation] Thrombotic angiopathyと補体 (2010)
  • Author(s): 水野正司
  • Organizer: 第47回補体シンポジウム
  • Place of Presentation: 福島
• [Presentation] 正常ラット腹膜における膜補体制御因子の機能的役割 (2010)
  • Author(s): 水野智博、水野正司, 他
  • Organizer: 第47回補体シンポジウム
  • Place of Presentation: 福島
• [Presentation] Membrane complement regulators may protect against encapsularperitoneal sclerosis(EPS) in a chronic prolife rative in flammation model of zymosan peritonitis in the rat (2010)
  • Author(s): Mizuno M, et al.
  • Organizer: XXII Inter nationalco mplement workshop
  • Place of Presentation: New York, USA
• [Presentation] Zymosan(Z)による増殖性腹膜炎モデルの作成と補体治療の可能性 (2010)
  • Author(s): 水野正司, 他
  • Organizer: 第55回日透析医学会学術集会・総会
  • Place of Presentation: 神戸
• [Presentation] 腹膜局所炎症は導入初期腹膜透過性と相関する (2010)
  • Author(s): 澤井晶穂, 他
  • Organizer: 第53回日本腎臓学会総会
  • Place of Presentation: 神戸
• [Presentation] Lym plangio genesis develop sduring tubulo-interstitial fibrosis in rat unilateral urethral obstruction via TGF-β-BEGF-C pathway (2010)
  • Author(s): Suzuki Y, et al.
  • Organizer: ISN NEXUS
  • Place of Presentation: Kyoto, Japan
• [Presentation] 名大腎不全システム研究会レジストリー、東海地区13施設の3年間(2005～2007)解析から得た、腹膜透析療法の傾向と問題点 (2009)
  • Author(s): 水野正司, 他
  • Organizer: 第15回 日本腹膜透析研究会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-28
• [Presentation] Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid. (2009)
  • Author(s): Mizuno T., et al.
  • Organizer: 12^<TH> European Meeting on Complement in Human Diseases
  • Place of Presentation: Visegrad, Hungary
  • Year and Date: 2009-09-05
• [Presentation] Zymosanによる増殖性腹膜炎ラットモデルの作成と補体治療の可能性 (2009)
  • Author(s): 水野正司
  • Organizer: 第46回 補体シンポジウム
  • Place of Presentation: 九州大学(福岡)
  • Year and Date: 2009-08-21
• [Presentation] 名大腎不全システム研究会レジストリー解析から得た、腹膜透析療法の傾向と問題点-東海地区13施設の3年間(2005～2007)の動向- (2009)
  • Author(s): 水野正司
  • Organizer: 第53回 日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-06
• [Presentation] 名大腎不全システム研究会レジストリー、東海地区13施設の3年間(2005～2007)解析から得た、腹膜透析療法の傾向と問題点 (2009)
  • Author(s): 水野正司, 他
  • Organizer: 第15回日本腹膜透析研究会総会・学術集会
  • Place of Presentation: 静岡
• [Presentation] Connective tissue growth factor(CCN2/CTGF) is increased in peritoneal dialysispatents with high peritoneal solute transport rate (2009)
  • Author(s): Ito Y, et al.
  • Organizer: The 9th European Peritoneal Dialysis Meeting
  • Place of Presentation: Strasbourg, France
• [Presentation] Peritoneal local inflammation is correlated with the baseline peritoneal solute transport rate in peritoneal dialysis patients (2009)
  • Author(s): Sawai A, et al.
  • Organizer: The 9th European Peritoneal Dialysis Meeting
  • Place of Presentation: Strasbourg, France
• [Presentation] Specific collaboration between rat membrane complemen tregulators Crry and CD59 protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid (2009)
  • Author(s): Mizuno T, Mizuno M, et al.
  • Organizer: 12^<th> European Meeting on Complement in Human Diseases
  • Place of Presentation: Visegrad, Hungary
• [Presentation] Zymosanによる増殖性腹膜炎ラットモデルの作成と補体治療の可能性 (2009)
  • Author(s): 水野正司, 他
  • Organizer: 第46回補体シンポジウム
  • Place of Presentation: 福岡
• [Presentation] 名大腎不全システム研究会レジストリー解析から得た (2009)
  • Author(s): 水野正司, 他
  • Organizer: 第53回日本透析医学会学術集会・総会
  • Place of Presentation: 横浜
• [Book] 7-4.血液透析と補体、編集大井洋之、木下タロウ、松下操、補体学への招 (2011)
  • Author(s): 水野正司
  • Publisher: メジカルビュー社
• [Book] 8-1.腎尿細管間質障害とと補体、編集大井洋之、木下タロウ、松下操、補体学への招待 (2011)
  • Author(s): 水野正司, 他
  • Publisher: メジカルビュー社
• [Book] 2. CKDの診断4)腎不全合併症の検索、編集松尾清一、インフォームドコンセントのための図説シリーズ慢性腎臓病(CKD) (2010)
  • Author(s): 水野正司
  • Publisher: 医薬ジャーナル社
• [Remarks]
  • URL: http://monnbudaigaku.com/tokyo/kakenhi/seika
• [Remarks]
  • URL: http://kenpro.mynu.jp:8001/Profiles/0014/0001480/profile.html