The development for new peritoneal dialysate to reduce oxidative stress and apoptosis using rare sugar
| Project/Area Number |
21591055
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Tohoku University (2010-2011)
Kagawa University (2009) |
|---|
Principal Investigator |
KIYOMOTO Hideyasu 東北大学, 東北メディカル・メガバンク機構, 教授 (00304585)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | 腹膜中皮細胞 / 希少糖 / D-プシコース / 酸化ストレス / 慢性腎不全 / 腹膜透析 / NADPHオキシターゼ / アポトーシス / 稀少糖 / NADPHオキシダーゼ |
|---|
| Research Abstract |
In order to clarify the protective fluid in peritoneal dialysis(PD), we investigated the effects of psicose, one of rare sugars, on peritoneal mesothelial cells(PMCs)injury induced by D-glucose. ROS production was significantly increased in PMCs treated with 83mM D-glucose containing medium. Both D-and L-psicose prevented the D-glucose induced ROS production via suppression of p22 phox, a NADPH oxidase membrane component. These results suggested that decrease of ROS production was possible mechanisms that psicose suppressed peritoneal deterioration. Then, we are focus the medical relevance in vivo animal models. We conclude that psicose containing dialysate may be beneficial effect on PMCs survival in PD therapy ; however it will be necessary to proof the concept in vivo animals.
|
Report
(4 results)
Research Products
(22 results)
-
[Journal Article] Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats2012
Author(s)
Sofue T, Kiyomoto H, Kobori H, Urushihara M, Nishijima Y, Kaifu K, Hara T, Matsumoto S, Ichimura A, Ohsaki H, Hitomi H, Kawachi H, Hayden MR, Whaley-Connell A, Sowers JR, Ito S, Kohno M, Nishiyama A.
-
Journal Title
Am J Hypertens
Volume: 25(5)
Pages: 604-11
Related Report
Peer Reviewed
-
-
[Journal Article] Angiotensin II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells2011
Author(s)
Hitomi H, Kaifu K, Fujita Y, Sofue T, Nakano D, Moriwaki K, Hara T, Kiyomoto H, Kohno M, Kobori H, Nishiyama A.
-
Journal Title
Am J Hypertens
Volume: 24(10)
Pages: 1149-55
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Regression ofsuperficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria : effect of angiotensin II blockade2010
Author(s)
Ihara G, Kiyomoto H, Kobori H, Nagai Y, Ohashi N, Hitomi H, Nakano D, Pelisch N, Hara T, Mori T, Ito S, Kohno M, Nishiyama A.
-
Journal Title
J Hypertens
Volume: 28
Pages: 2289-98
Related Report
Peer Reviewed
-
[Journal Article] Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells2010
Author(s)
Kaifu K, Kiyomoto H, Hitomi H, Matsubara K, Hara T, Moriwaki K, Ihara G, Fujita Y, Sugasawa S, Nagata D, Nishiyama A, Kohno M.
-
Journal Title
Nephrol Dial Transplant
Volume: 24(3)
Pages: 809-815
Related Report
Peer Reviewed
-
[Journal Article] Involvement of mineralocorticoid receptor in high glucose-induced big mitogen-activated protein kinase 1 activation and mesangial cell proliferation2010
Author(s)
Liu G, Miyata K, Hitomi H, Yao L, Sun GP, Suzaki Y, Hosomi N, Kiyomoto H, Nakano D, Tamaki T, Yoshizumi M, Nishiyama A.
-
Journal Title
J Hypertens
Volume: 28(3)
Pages: 536-42
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
