elucidation of physiological roles of prostasin and its signaling pathway
| Project/Area Number |
21591056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
SHIRAISHI Naoki 熊本大学, 大学院・生命科学研究部, 助教 (40423660)
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| Co-Investigator(Kenkyū-buntansha) |
TOMITA Kimio 熊本大学, 大学院・生命科学研究部, 教授 (40114772)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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|---|
| Keywords | シグナル伝達 / 生体分子 / 生理活性 |
|---|
| Research Abstract |
We demonstrated that addition of recombinant prostasin to human adrenocortical cells increased secretion of aldosterone to the media in a dose dependent manner. We also showed that camostat mesilate, a potent serine-protease inhibitor, suppressed the progression of renal injury in aldosterone-induced renal injury model rats and in 5/6 nephrectomized renal failure model rats. Since camostat has been already clinically used as a medicine for pancreatitis and esophagitis in Japan, early clinical application of camostat for renal failure can be expected.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Regulation of adrenal aldosterone production by serine protease prostasin2010
Author(s)
Ko T, Kakizoe Y, Wakida N, Hayata M, Uchimura K, Shiraishi N, Miyoshi T, Adachi M, Aritomi S, Konda T, Tomita K, Kitamura K
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Journal Title
J Biomed Biotechnol
Pages: 793843-793843
Related Report
Peer Reviewed
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[Journal Article] Aberrant ENaC activation in Dahl salt-sensitive rats2009
Author(s)
Kakizoe Y, Kitamura K, Ko T, Wakida N, Maekawa A, Miyoshi T, Shiraishi N, Adachi M, Zhang Z, Masilamani S, Tomita K
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Journal Title
J Hypertens
Volume: 27(8)
Pages: 1679-89
Related Report
Peer Reviewed
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[Presentation] アルドステロンによる上波型Naチャネル活性化におけるセリンプロテアーゼ阻害薬の効果2011
Author(s)
柿添豊, 北村健一郎, 内村幸平, 早田学, 森永潤, 尾上友朗, 水本輝彦, 安達政隆, 實吉拓, 白石直樹, 酒井芳紀, 冨田公夫
Organizer
第54回日本腎臓学会学術総会
Place of Presentation
パシフィコ横浜
Year and Date
2011-06-16
Related Report
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[Presentation] 片側尿管結紮モデル(UUO)ラットにおけるメシル酸カモスタットの効果2011
Author(s)
森永潤, 北村健一郎, 尾上友朗, 水本輝彦, 内村幸平, 早田学, 柿添豊, 安達政隆, 實吉拓, 白石直樹, 酒井芳紀, 冨田公夫
Organizer
第54回日本腎臓学会学術総会
Place of Presentation
パシフィコ横浜
Year and Date
2011-06-15
Related Report
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[Presentation] A synthetic serine protease inhibitor camostat mesilate inhibited the proteolytic activation of gENaC in the kidney of the aldosterone-infused rats2011
Author(s)
Uchimura-K, Kakizoe-Y, Onoue-T, Hayata-M, Morinaga-J, Mizumoto-T, Adachi-M, Miyoshi-T, Shiraishi-N, Sakai-Y, Tomita-K, Kitamura-K
Organizer
American Society of Nephrology Kidney Week 2011
Place of Presentation
Pennsylvania Convention Center, Philadelphia, PA
Related Report
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[Presentation] A synthetic serine protease inhibitor camostat mesilate attenuates renal interstitial fibrosis in rats2011
Author(s)
Morinaga-J, Kakizoe-Y, Miyoshi-T, Onoue-T, Mizumoto-T, Hayata-M, Uchimura-K, Shiraishi-N, Adachi-M, Sakai-Y, Tomita-K, Kitamura-K
Organizer
American Society of Nephrology Kidney Week 2011
Place of Presentation
Pennsylvania Convention Center, Philadelphia, PA
Related Report
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