Regulation of sodium metabolism and hypertension by HAI-1B.
| Project/Area Number |
21591057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
MIYOSHI Taku 熊本大学, 大学院・生命科学研究部, 助教 (80398205)
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| Co-Investigator(Kenkyū-buntansha) |
TOMITA Kimio 熊本大学, 大学院・生命科学研究部, 教授 (40114772)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 高血圧 / ナトリウム / HAI-1B / プロスタシン / HAI1-B / 上皮型Naチャネル / 食塩感受性高血圧 / HAI-1 |
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| Research Abstract |
HAI-1B is one of endogenous serine protease inhibitors. It expresses with prostasin in several organs, and acts as a regulator of prostasin. We elucidated that overexpression of HAI-1B decreased sodium current caused by ENaC, and we purified HAI-1B recombinant protein from silkworm hemolymph. We are preparing construction of renal collecting duct cell-specific HAI-1B knockout mice
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Report
(4 results)
Research Products
(13 results)
