Role of bone marrow-derived mononuclear cells on modulation of brain renin-angiotensin system

• Project/Area Number: 21591059
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: University of the Ryukyus
• Principal Investigator: YAMAZATO Masanobu 琉球大学, 医学研究科, 助教 (90347138)
• Co-Investigator(Kenkyū-buntansha): ISHIDA Akio 琉球大学, 医学部附属病院, 講師 (10343378)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 高血圧学 / 中枢性血圧調節 / 高血圧 / 骨髄由来間葉系幹細胞 / 脳室内投与 / 骨髄由来単核球細胞

Research Abstract

We hypothesized that decreased number or function of bone marrow(BM)-derived cells in the brain is related to neurogenic hypertension. Intracerebroventricular(icv) administration of DiI labeled BM-derived cells revealed that a long term attachment of DiI positive cell in the brain. Although icv administration of BM-derived cells did not alter blood pressure in hypertensive rats, higher expression of angiotensin converting enzyme 2(ACE2) and Mn-SOD of the BM-derived cells and its ability to attach in the brain suggest that BM-derived cells may serve as a mobile renin-angiotensin system modulator in the brain.

Research Products

• [Presentation] 骨髄由来細胞のレニンーアンジオテンシン系構成要素発現の特徴と脳での循環動態に及ぼす影響 (2011)
  • Author(s): 山里正演、石田明夫、山里代利子、崎間敦、安隆則、大屋祐輔
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木県宇都宮市
  • Year and Date: 2011-10-22
• [Presentation] Bone marrow derived cells express higher angiotensin-converting enzyme 2(ACE2) and its ability to attach in the brain of hypertensive rats (2011)
  • Author(s): Yamazato M, Ishida A, Yamazato Y, Sakima A, Yasu T, Ohya Y.
  • Organizer: AHA High Blood Pressure Research 2011Scientific Sessions, Sept 22
  • Place of Presentation: Orlando, FL.
  • Year and Date: 2011-09-22
• [Presentation] Bone marrow derived cells express higher angiotens in-converting enzyme 2 (ACE2) and its ability to attach in the brain of hypertensive rats (2011)
  • Author(s): Masanobu Yamazato, Akio Ishida, Yoriko Yamazato, Atsushi Sakima, Takanori Yasu, Yusuke Ohya
  • Organizer: American Heart Association, High Blood Pressure Research 2011 Scientific Sessions
  • Place of Presentation: Orlando, FL
  • Year and Date: 2011-09-22
• [Remarks]
  • URL: http://www.hosp.u-ryukyu.ac.jp/med3/3naika/home.html