Improvement of biocompatibility of dialysis membrane by nitric oxide or hydrogen
| Project/Area Number |
21591060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
KOKUBO Kenichi 北里大学, 医療衛生学部, 准教授 (20287965)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hirosuke 北里大学, 医療衛生学部, 教授 (70153632)
SHINBO Toshihiro 東京工科大学, 医療保健学部, 助教 (10406910)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 人工透析学 / 生体適合性 / 血液透析膜 / 一酸化窒素ガス / 血小板活性化 / マウス透析システム / 超小型透析システム |
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| Research Abstract |
The aim of the present study was to improve biocompatibility of dialysis membrane by releasing nitric oxide(NO) or hydrogen gas from the dialysate. The system we developed can release sufficient amount of NO from dialysate to blood. The NO released from the dialysis membrane surface suppressed platelet activation without formation of excess methemoglobin.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] Dialysate containing nitric oxide suppresses platelet activation on the surface of dialysis membrane2012
Author(s)
Kokubo K, Urabe S, Hanada S, Ebine T, Tsukao H, Shinbo T, Hirose M, Kobayashi H
Organizer
7th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
Place of Presentation
Edinburgh, UK
Related Report
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