Improvement of biocompatibility of dialysis membrane by nitric oxide or hydrogen

• Project/Area Number: 21591060
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kitasato University
• Principal Investigator: KOKUBO Kenichi 北里大学, 医療衛生学部, 准教授 (20287965)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Hirosuke 北里大学, 医療衛生学部, 教授 (70153632) ; SHINBO Toshihiro 東京工科大学, 医療保健学部, 助教 (10406910)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 人工透析学 / 生体適合性 / 血液透析膜 / 一酸化窒素ガス / 血小板活性化 / マウス透析システム / 超小型透析システム

Research Abstract

The aim of the present study was to improve biocompatibility of dialysis membrane by releasing nitric oxide(NO) or hydrogen gas from the dialysate. The system we developed can release sufficient amount of NO from dialysate to blood. The NO released from the dialysis membrane surface suppressed platelet activation without formation of excess methemoglobin.

Research Products

• [Presentation] Dialysate containing nitric oxide suppresses platelet activation on the surface of dialysis membrane (2012)
  • Author(s): Kokubo K, Urabe S, Hanada S, Ebine T, Tsukao H, Shinbo T, Hirose M, Kobayashi H
  • Organizer: 7th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh, UK
• [Presentation] Suppression of platelet activation on the surface of dialysis membrane using nitric oxide containing dialysate (2011)
  • Author(s): Urabe S, Kokubo K, Tsukao H, Shinbo T, Hirose M, Kobayashi H
  • Organizer: 47th ERA-EDTA Congress
  • Place of Presentation: Prague, Czech republic
• [Presentation] 一酸化窒素供与体を用いた血液透析における血小板凝集の抑制 (2011)
  • Author(s): 浦辺俊一郎, 小久保謙一, 塚尾浩, 新保年弘, 廣瀬稔, 小林弘祐
  • Organizer: 日本医工学治療学会第27回学術大会
  • Place of Presentation: 岡山
• [Presentation] 一酸化窒素供与体を用いた血液透析における血小板凝集の抑制 (2011)
  • Author(s): 浦辺俊一郎, 小久保謙一, 塚尾浩, 新保年弘, 廣瀬稔, 小林弘祐
  • Organizer: 日本医工学治療学会第27回学術大会
  • Place of Presentation: 岡山コンベンションセンター(岡山)
• [Presentation] Suppression of platelet activation on the surface of dialysis membrane using nitric oxide containing dialysate (2011)
  • Author(s): Urabe S, Kokubo K, Tsukao H, Shinbo T, Hirose M, Kobayashi H
  • Organizer: 47^<th> ERA-EDTA Congress
  • Place of Presentation: Prague Congress Centre (Prague, Czech republic)
• [Presentation] Suppression of platelet Activation on the surface of dialysis membrane releasing nitric oxide from the dialysate (2010)
  • Author(s): Urabe S, Kokubo K, Tsukao H, Shinbo T, Hirose M, Kobayashi H
  • Organizer: 47th ERA-EDTA Congress
  • Place of Presentation: Munich
• [Presentation] Dialysis membrane releasing nitric oxide from dialysate side increases cyclic guanosine monophosphate in platelets and suppresses the activation of platelets on the surface (2010)
  • Author(s): Kokubo K, Urabe S, Tsukao H, Shinbo T, Hirose M, Kobayashi H
  • Organizer: 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto, Japan
• [Presentation] Suppression of platelet Activation on the surface of dialysis membrane releasing nitric oxide from the dialysate. (2010)
  • Author(s): Shunichiro Urabe, Kenichi Kokubo, Hiroshi Tsukao, Toshihiro Shinbo, Minoru Hirose, Hirosuke Kobayashi
  • Organizer: 47^<th> ERA-EDTA Congress
  • Place of Presentation: International Congress Centre Munich, Munich, Germany
• [Presentation] Dialysis membrane releasing nitric oxide from dialysate side increases cyclic guanosine monophosphate in platelets and suppresses the activation of platelets on the surface. (2010)
  • Author(s): Kenichi Kokubo, Shunichiro Urabe, Hiroshi Tsukao, Toshihiro Shinbo, Minoru Hirose, Hirosuke Kobayashi
  • Organizer: 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: 国立京都国際会館,京都
• [Book] 各種治療モードとその特徴 (2012)
  • Author(s): 小久保謙一, 酒井清孝, 峰島三千男
  • Publisher: 南江堂
• [Book] 血液透析の原理と構成 (2010)
  • Author(s): 小久保謙一.竹澤慎吾, 出渕靖志
  • Publisher: 医歯薬
• [Book] 生体と医用材料の相互作用,臨床工学講座生体物性・医用材料工学 (2010)
  • Author(s): 小久保謙一.氏平政伸, 中島章夫
  • Publisher: 医歯薬