| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
It has been reported to be some similarities in pathological findings on heart between uremic cardiomyopathy(UC) and idiopathic dilated cardiomyopathy(DCM). The fact suggests that autoimmunological mechanism involve in the pathomechanism of UC, which is likely to be multifactorial. We examined the role of autoimmunological mechanism in the pathogenesis of US in experimental and clinical studies. Anti-myocardium antibodies were more prevalent in patients with CKD, compared with subjects with normal kidney function. Among there antibodies, anti-adrenergic receptor antibody(β1ARAb) was frequently found in patients with advanced CKD. In addition, β1ARAb was significantly associated with lower left ventricular function in patients on hemodialysis. We found that removal of. 1ARAb by DFPP(double filtration plasmapheresis) was very effective in dialysis patients with high titer of βARAb, who suffered from severe heart failure due to UC. Taken together, the results suggest that autoimmulogical mechanism plays a crucial role in the pathogenesis of UC.
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