The role of vasopressin V1a receptor in diabetic nephropathy and the invention of new therapy.
| Project/Area Number |
21591064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Takeshi 兵庫医科大学, 医学部, 教授 (70217769)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMITA Kimio 熊本大学, 大学院・生命科学研究部, 教授 (40114772)
KAWAHARA Kastumasa 北里大学, 医学部, 教授 (70134525)
NAKAYAMA Yushi 熊本大学, 大学院・生命科学研究部, 講師 (00363531)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 水・電解質代謝学 / 抗利尿ホルモン / レニン・アンジオテンシン・アルドステロン系 / ミネラルコルチコイド受容体 / 細胞質核内輸送 / V1a受容体 / アルドステロン / 腎尿細管性アシドーシス / ミネラロコルチコイド受容体 / 細胞質・核輸送 / 核内受容体 / 介在細胞 / V2受容体 / ノックダウン / 抗体利尿ホルモン / ノックアウトマウス / トランスジェニックラット / H-ATPase |
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| Research Abstract |
We reported that vasopressin V1a receptor deficient mice show type 4 renal tubular acidosis, which is characterized by reduced renal function, metabolic acidosis and hyperkalemia. Since the colleting ducts are the main cite of acid secretion by the kidney, we established a new cell line of the intercalated cells(IN-IC cells) from SV40 large T antigen Tg rats. Using these cells, we also found that vasopressin V1a receptor is required for nucleocytoplasmic transport of mineralocorticoid receptor by aldosterone in the intercalated cells. In conclusion, vasopressin V1a receptor is essential for acid-base regulation by aldosterone in intercalated cells. These data suggest the possibility of clinical use of vasopressin V1a receptor antagonist as an aldosterone antagonist.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] High Levels of Tumor Necrosis Factor-α Downregulate Antimicrobial Iron Transport Protein, Nramp1, in Chronic Hemodialysis Patients : A Key Factor for Infection Risk2012
Author(s)
Moriguchi R, Otaki Y, Hazeki S, Shimada T, Matsumoto A, Kakita N, Kaibe S, Kuragano T, Nonoguchi H, Masayoshi N, Hasuike Y, Nakanishi T.
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Journal Title
Am J Nephrol
Volume: 35(4)
Pages: 372-8
Related Report
Peer Reviewed
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[Journal Article] Persistent homocysteine metabolism abnormality accelerates cardiovascular disease in hemodialyzed patients--the Nishinomiya Study2012
Author(s)
Hasuike Y, Hama Y, Nonoguchi H, Hori K, Tokuyama M, Toyoda K, Hazeki S, Nanami M, Otaki Y, Kuragano T, Nakanishi T.
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Journal Title
J Ren Nutr
Volume: 22(1)
Pages: 12-8
Related Report
Peer Reviewed
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[Journal Article] Aldosterone requires vasopressin V1a receptors on intercalated cells to mediate acid-base homeostasis2011
Author(s)
Izumi Y, Hori K, Nakayama Y, Kimura M, Hasuike Y, Nanami M, Kohda Y, Otaki Y, Kuragano T, Obinata M, Kawahara K, Tanoue A, Tomita K, Nakanishi T, NonoguchiH.
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Journal Title
J Am Soc Nephrol
Volume: 22(4)
Pages: 673-80
Related Report
Peer Reviewed
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[Journal Article] Therapeutic efficacy of double filtration plasmapheresis in patients with anti-aquaporin-4 antibody-positive multiple sclerosis2011
Author(s)
Munemoto M, Otaki Y, Kasama S, Nanami M, Tokuyama M, Yahiro M, Hasuike Y, Kuragano T, Yoshikawa H, Nonoguchi H, Nakanishi T.
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Journal Title
J Clin Neurosci
Volume: 18(4)
Pages: 478-80
Related Report
Peer Reviewed
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[Presentation] Vasopressin V1a Receptor is required for Nucleocytoplasmic Transport of Minerelocorticid Receptor2011
Author(s)
Nagai T, Hori K, Izumi Y, Hasuike Y, Nakayama Y, Nanami M, Otaki Y, Tomita K, Kawahara K, TanoueA, Nakanishi T, Nonoguchi H.
Organizer
44th Annual Meeting of the American Society of Nephrology
Place of Presentation
Philadelphia, USA
Related Report
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[Presentation] Mechanisms of Type 4(hyperkalemic) Renal Tubular Acidosis2010
Author(s)
Hori K, Nagai T, Izumi Y, Nakayama Y, Hasuike Y, Nanami M, Yasuoka Y, Otaki Y, Tanoue A, Kawahara K, Tomita K, Nakanishi T, Nonoguchi H.
Organizer
43rd Annual Meeting of the American Society of Nephrology
Place of Presentation
Denver, USA
Related Report
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[Presentation] Regulation of aldosterone action by vasopressin V1a receptor in the intercalated cell2009
Author(s)
Hori K, Kimura M, Izumi Y, Nakayama Y, Memetimin H, Kida A, Hasuike Y, Otaki Y, Tomita K, Tanoue A, Nakanishi T, Nonoguchi H
Organizer
42nd Annual Meeting of the American Society of Nephrology
Place of Presentation
San Diego, USA
Related Report
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