| Project/Area Number |
21591071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMAOKA Akira 筑波大学, 医学医療系, 教授 (50192183)
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| Co-Investigator(Renkei-kenkyūsha) |
KWAK Shin 東京大学, 医学部・附属病院, 准教授 (40160981)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 筋萎縮性側索硬 サ症 / RNA編集 / 多因子 / 電気穿孔法 / TDP-43 / 筋萎縮性側索硬化症 / 細胞死 / ADAR2 / ウイルスベクター / Progranulin / 初代培養系 |
|---|
| Research Abstract |
To examine the effect of multi-factorial involvement, such as RNA-editing enzyme, in the typical neurodegenerative disease, amyotrophic lateral sclerosis (ALS), I established the model for neuronal cell death. For in vitro study, adenovirus system was developed, and for in vivo study the gene-transfer system by electroporation for embryo mice was developed. These systems are very useful for studying multi-factorial system because many genes can be introduced into simultaneously and easily.
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