| Project/Area Number |
21591074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KANEKO Kazuma 信州大学, 医学部, 助教 (80402105)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 神経分子病態学 / アミロイドーシス / 遊離軽鎖 / 免疫グロブリン関連アミロイド / 末梢神経 / 神経毒性 |
|---|
| Research Abstract |
The present study investigated whether or not plasma free light chains(FLC) of the patients with immunoglobulin-related amyloidosis have neurotoxicity. We cultured rat dorsal root ganglion neurons at various concentrations of purified FLC, and compared percentage of neurons with neirites, diameter of neurons, neurite number per neuron, length of the longest neurite in each neuron and total neurite length per neuron with those of controls. FLC of the immunoglobulin-related amyloidosis patients showed significant decreases in all of these parameters except for diameter of neurons compared with controls irrespective of the presence of clinically apparent peripheral neuropathy.
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