| Project/Area Number |
21591076
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
KOIKE Huaruki 名古屋大学, 医学部附属病院, 病院助教 (80378174)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITO Mizuki 名古屋大学, 医学系研究科, 特任助教 (50437042)
IIJIMA Masahiro 名古屋大学, 医学系研究科, COE,特任助教 (40437041)
TANAKA Fumiaki 名古屋大学, 医学系研究科, 准教授 (30378012)
祖父江 元 名古屋大学, 大学院・医学系研究科, 教授 (20148315)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | アミロイド / トランスサイレチン / 家族性アミロイドポリニューロパチー / 多発神経炎 |
|---|
| Research Abstract |
We assessed clinicopathological features of FAP ATTR Val30Met patients in Japan by comparing those of conventional early-onset cases from endemic foci to those of late-onset ones from non-endemic areas. Patients with FAP ATTR Val30Met from endemic foci and those from non-endemic areas show different clinical, electrophysiological, and histopathological features. As compared to a classic phenotype of FAP, clinicopathological features of patients from non-endemic areas tend to be nonspecific. Physicians may not take the possibility of FAP into consideration until amyloid became evident by sural nerve biopsy. Therefore, tight recognition for the possibility of FAP ATTR Val30Met are needed at the time of initial evaluation of neuropathy of undetermined etiology to avoid missed diagnosis.
|
