| Project/Area Number |
21591087
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Kyushu University (2011)
Ehime University (2009-2010) |
|---|
Principal Investigator |
KAWANO Yuji 九州大学, 医学研究院, 特任講師 (20333479)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIKI Tetsurou 愛媛大学, プロテオ医学研究センター, 教授 (00174003)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 神経難病 / 多発性硬化症 / 筋萎縮性側索硬化症 / microRNA / 疾患感受性遺伝子 / ALS / MS |
|---|
| Research Abstract |
In this study, it is aimed for the elucidation of the role of microRNA in the neurologic intractable disease. The 3' UTR of disease-related genes, which is estimated to be regulated by microRNA, were proceeded to determine the entire sequence in the patient to the extent possible. For multiple sclerosis, a total of 14 genes, such as IL2RA and IL7R was selected. With respect to amyotrophic lateral sclerosis, we selected a total of 16 genes such as FUS and Alsin. The significant mutation by a patient by each gene was not found, but we assumed that I was planning to synthesize the result and data with other projects.
|
