| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
To clarify the role of autoimmune response to claudin domain containing 1(CLDND1) in multiple sclerosis(MS), we measured serum anti-CLDND1 autoantibody in MS patients. We found a significant increase in anti-CLDND1 seropositivity in anti-aquaporin-4 antibody positive MS patients(41. 2%) compared with controls(3. 2%). CLDND1 was expressed in the myelin, neuron and endothelial cell in the central nervous system. The result of our study suggest that the autoimmune response to CLDND1 is related with demyelination and distraction of BBB in anti-AQP4 antibody positive MS.
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