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Study on the development of treatments for collagen VI related myopathy.

Research Project

Project/Area Number 21591094
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKagoshima University

Principal Investigator

HIGUCHI Itsuro  鹿児島大学, 医学部・歯学部附属病院, 講師 (80183573)

Co-Investigator(Kenkyū-buntansha) TAKASHIMA Hiroshi  鹿児島大学, 大学院・医歯学総合研究科, 教授 (80372803)
ARIMURA Kimiyoshi  鹿児島大学, 大学院・医歯学総合研究科, 准教授 (30140908)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords6型コラーゲン / Ullrich病 / Bethlemミオパチー / 関節拘縮 / thrombomodulin / 実験的治療 / 細胞接着 / ウルリッヒ病 / ベスレムミオパチー / collagen VI / Ullrich型先天性筋ジストロティー / 皮膚線維芽細胞 / コラーゲンVI
Research Abstract

We have been continuing a long-term follow-up of collagen VI related diseases as Ullrich disease and Bethlem myopathy. The main cause of difficulty in walking in Bethlem myopathy was joint contracture, and the ambulatory period was extended by the orthopedic treatment. We have been performing genetic analysis of genes of collagen VI and related proteins. We found that recombinant thrombomodulin can improve the adhesive capacity of fibroblasts and increase the expression of collagen VI in Ullrich disease.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 7 results) Presentation (4 results)

  • [Journal Article] コラーゲン6型変異によるミオパチー2011

    • Author(s)
      樋口逸郎
    • Journal Title

      Brain and Nerve

      Volume: 63(11) Pages: 1169-1178

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] A new mitochondria-related disease showing myopathy with episodic hyper-creatine kinase-emia2011

    • Author(s)
      Okamoto Y, Higuchi I, Sakiyama Y, Tokunaga S, Watanabe O, Arimura K, Nakagawa M, Takashima H.
    • Journal Title

      Ann Neurol

      Volume: 70(3) Pages: 486-492

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new phenotype of mitochondrial disease characterized by familial late-onset predominant axial myopathy and encephalopathy2011

    • Author(s)
      Sakiyama Y, Okamoto Y, Higuchi I, Inamori Y, Sangatsuda Y, Michizono K, Watanabe O, Hatakeyama H, Goto Y, Arimura K, Takashima H.
    • Journal Title

      Acta Neuropathol

      Volume: 121(6) Pages: 775-783

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological differences between human T-lymphotropic virus type 1-positive and human T-lymphotropic virus type 1-negative polymyositis2011

    • Author(s)
      Abdullah HM, Higuchi I, Kubota R, Matsuura E, Hashiguchi A, Abdelbary NH, Inamori Y, Takashima H, Izumo S.
    • Journal Title

      Clinical and Experimental Neuroimmunology

      Volume: 2 Pages: 12-24

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial DNA deletion mutations in patients with neuropsychiatric symptoms2011

    • Author(s)
      Kato M, Nakamura M, Ichiba M, Tomiyasu A, Shimo H, Higuchi I, Ueno S, Sano A.
    • Journal Title

      Neurosci Res

      Volume: 69 Pages: 331-336

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new mitochondria-related disease showing myopathy with episodic hyper-creatine kinase-emia2011

    • Author(s)
      Okamoto Y, Higuchi I, Sakiyama Y, et al
    • Journal Title

      Ann Neurol

      Volume: 70 Issue: 3 Pages: 486-492

    • DOI

      10.1002/ana.22498

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new phenotype of mitochondrial disease characterized by familial late-onset predominant axial myopathy and encephalopathy2011

    • Author(s)
      Sakiyama Y, Okamoto Y, Higuchi I, et al
    • Journal Title

      Acta Neuropathol

      Volume: 121 Issue: 6 Pages: 775-783

    • DOI

      10.1007/s00401-011-0818-y

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ullrich病の筋病理2009

    • Author(s)
      樋口逸郎
    • Journal Title

      神経内科

      Volume: 71(4) Pages: 360-368

    • Related Report
      2011 Final Research Report
  • [Journal Article] Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase2009

    • Author(s)
      Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, Nakajima T.
    • Journal Title

      Int J Mol Med

      Volume: 24 Pages: 605-611

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 整形外科医に必用な筋疾患の知識2009

    • Author(s)
      樋口逸郎
    • Journal Title

      日本整形外科学会雑誌

      Volume: 83 Pages: 218-230

    • Related Report
      2011 Final Research Report
  • [Journal Article] 整形外科医に必用な筋疾患の知識2009

    • Author(s)
      樋口逸郎
    • Journal Title

      日本整形外科学会雑誌 83

    • Related Report
      2009 Annual Research Report
  • [Presentation] Immunohistochemical studies on HSP47 and vessel related proteins in inclusion body myositis and muscular dystrophies2010

    • Author(s)
      Itsuro Higuchi, Yukie Inamori, Keiko Higashi, Eiji Matsuura, Akihiro Hashiguchi, Tadafumi Shiraishi, Noriko Hirata, Kimiyoshi Arimura
    • Organizer
      12th International Congress on Neuromuscular Diseases
    • Place of Presentation
      Naples
    • Year and Date
      2010-07-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunohistochemical studies on HSP47 and vessel related proteins in inclusion body myositis and muscular dystrophies.2010

    • Author(s)
      Itsuro Higuchi, Yukie Inamori, Keiko Higashi, Eiji Matsuura, Akihiro Hashiguchi, Tadafumi Shiraishi, Noriko Hirata, Kimiyoshi Arimura
    • Organizer
      12th International Congress on Neuromuscular Diseases
    • Place of Presentation
      Naples, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] コラーゲンVI欠損UCMD患者の皮膚線維芽細胞に対するthrombomodulinの作用2009

    • Author(s)
      白石匡史、樋口逸郎、橋口照人、末原雅人、丸山征郎
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] コラーゲンVI欠損UCMD患者の皮膚線維芽細胞に対する thrombomodulin の作用2009

    • Author(s)
      白石匡史, 樋口逸郎, ほか
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台市
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2018-02-02  

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