Therapeutic strategy for muscular dystrophy by restoring the function of dystroglycan
Project/Area Number |
21591099
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Teikyo University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
SAITO Fumiaki 帝京大学, 医学部, 講師 (40286993)
HAGIWARA Hiroki 帝京大学, 医学部, 客員准教授 (80276732)
SHIMIZU Teruo 帝京大学, 医療技術学部, 教授 (00107666)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 神経分子病態学 / 筋ジストロフィー / ジストログリカン / ラミニン / LARGE / 糖鎖修飾 / 分子標的治療 / 福山型先天性筋ジストロフィー / 脳神経疾患 / 翻訳後修飾 / 糖転移酵素 / 糖鎖 / Large |
Research Abstract |
We generated transgenic mice overexpressing a glycosyltransferase, LARGE. The mice were born and grew normally, and laminin binding activity of dystroglycan was greatly increased in the skeletal muscle. We crossed the transgenic mice with dy^<2J> mice, a mouse model of congenital muscular dystrophy, to examin therapeutic effect of LARGE overexpression. The dystrophic change of dy^<2J> mice overexpressing LARGE, however, was not improved and the degeneration of myofibers was rather deteriorated.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Defective glycosylation of α-dystroglycan contributes to podocyte flattening.2010
Author(s)
Kojima K, Nosaka H, Kishimoto Y, Nishiyama Y, Fukuda S, Shimada M, Kodaka K, Saito F, Matsumura K, Shimizu T, Toda T, Takeda S, Kawachi H, Uchida S.
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Journal Title
Kidney International
Volume: 79
Pages: 311-316
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
Saito F, Matsumura K.
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Journal Title
Neurochemistry : Mollecular aspects, cellular aspects and clinical applications(NOVA Science Publishers, Inc. New York)
Pages: 195-209
Related Report
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