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An analysis of endothelial activation under cerebral ischemia using liposomes, which targets E-selectin.

Research Project

Project/Area Number 21591106
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionFujita Health University (2011)
National Center for Geriatrics and Gerontology (2009-2010)

Principal Investigator

WAKITA Hideaki  藤田保健衛生大学, 医学部・内科, 教授 (80416172)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords神経分子病態学 / 脳血管障害 / 炎症 / 神経科学 / 脳神経疾患 / 発現制御
Research Abstract

A novel liposome conjugated to Sialyl Lewis X(SLX-liposome), which targets E-selectin has been developed. In this study, we investigated the capacity of SLX-liposome containing anti-inflammatory agent for neuroprotection in cerebral ischemia using a rat model of transient middle cerebral artery occlusion(TMCAO). SLX-liposomes blocked E-selectin on luminal endothelium and attenuated infarct volume after TMCAO. These results suggest that SLX-liposomes have the potential for the treatment targeted to endothelial cells in acute ischemic stroke.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Dental pulp derived CD31-/CD146-side population stem/progenitor cells enhance recovery of focal cerebral ischemia in rats2011

    • Author(s)
      Sugiyama M, Iohara K, Wakita H, Hattori H, Ueda M, Matsushita K, Nakashima M
    • Journal Title

      Tissue Engineering Part A

      Volume: 17(9-10) Issue: 9-10 Pages: 1303-1311

    • DOI

      10.1089/ten.tea.2010.0306

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Watershed Infarcts in a multiple microembolic model of monkey2011

    • Author(s)
      Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H
    • Journal Title

      Neuroscience Letters

      Volume: 499 Issue: 2 Pages: 80-83

    • DOI

      10.1016/j.neulet.2011.05.036

    • NAID

      120003238944

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] E-selectin targeting to visualize tumors in vivo2010

    • Author(s)
      Hirai M, Hiramatsu Y, Iwashita S, Otani T, Chen L, Li YG, Okada M, Oie K, Igarashi K, Wakita H, Seno M
    • Journal Title

      Contrast Media & Molecular Imaging

      Volume: 5(2) Issue: 2 Pages: 70-77

    • DOI

      10.1002/cmmi.367

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] miRNAによるE-selectinの抑制2010

    • Author(s)
      吉崎嘉一、脇田英明、大隅典子、高橋慶吉
    • Journal Title

      炎症と免疫

      Volume: 18(2) Pages: 130-134

    • Related Report
      2011 Final Research Report
  • [Journal Article] E-selectin targeting to visualize tumors in vivo.2010

    • Author(s)
      Hirai M, Hiramatsu Y, Iwashita S, Otani T, Chen L, Li Y G, Okada M, Oie K, Igarashi K, Wakita H, Seno M
    • Journal Title

      Contrast Media & Molecular Imaging

      Volume: VOL.5 Pages: 70-77

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] E-selectinを標的としたリポソームによる細胞接着分子阻止とグリア細胞活性化の抑制2011

    • Author(s)
      脇田英明、足立香代、丸山和佳子
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管性認知症の実験モデル(シンポジウム1,血管性認知症のニューホライズン)2010

    • Author(s)
      脇田英明
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] E-selectinを標的としたリポソームによる細胞接着分子阻止とグリア細胞活性化の抑制2010

    • Author(s)
      脇田英明、足立香代
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-22
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] セレクチンを標的としたリポソームによる細胞接着分子抑制効果の検討2010

    • Author(s)
      脇田英明、足立香代
    • Organizer
      第35回日本脳卒中学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-16
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] マウス血管性認知症モデルに対するSialyl Lewis X結合リポソームの有効性の検討2010

    • Author(s)
      脇田英明、足立香代、武田和也、國本正子、渡邉淳、丸山和佳子
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] マウス血管性認知症モデル白質病変での細胞接着分子発現とグリア細胞活性化の検討2009

    • Author(s)
      脇田英明、吉崎嘉一
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-22
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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