Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Research Abstract |
A novel liposome conjugated to Sialyl Lewis X(SLX-liposome), which targets E-selectin has been developed. In this study, we investigated the capacity of SLX-liposome containing anti-inflammatory agent for neuroprotection in cerebral ischemia using a rat model of transient middle cerebral artery occlusion(TMCAO). SLX-liposomes blocked E-selectin on luminal endothelium and attenuated infarct volume after TMCAO. These results suggest that SLX-liposomes have the potential for the treatment targeted to endothelial cells in acute ischemic stroke.
|