| Project/Area Number |
21591109
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIZAWA Masatoyo 新潟大学, 脳研究所, 教授 (80198457)
TAKAHASHI Hitoshi 新潟大学, 脳研究所, 教授 (90206839)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | アルファシヌクレイン / シヌクレイノパチー / 消化管神経 / パーキンソン病 / 多系統萎縮症 / グレリン / 消化管機能 / 消化管神経叢 / 神経変性 / 腸音解析 / 便秘 |
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| Research Abstract |
To elucidate the pathogenic mechanism of enteric neurodegeneration in Parkinson's disease(PD) and related disorders, we investigated the frequency of bowel sounds, the state of ghrelin secretion into plasma, and histopathological changes of the enteric nervous system. The results showed that the frequency of bowel sounds and the active ghrelin ratio was significantly lower in patients with PD and multiple system atrophy(MSA) than in control subjects. These observations suggested that enteric nervous system functionally related to gastrointestinal motility and controlling ghrelin secretion was affected in both PD and MSA. Regarding the histopathological changes of the enteric nervous system, Lewy bodies were seen in PD cases ; however, there was no alpha-synuclein positive inclusion in the enteric nervous system in MSA cases. Further investigations are needed to determine neurodegenerative changes of the enteric nervous system in PD and MSA cases.
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