| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
The relationship between the aggregation of TDP-43 in the and the degeneration of pyramidal truct in the upper motor neurons was analyzed in ALS cases, which was not significantly observed. In ALS1 model mice, phosphorylated TDP-43 was observed in the white matter of spinal cord, suggesting that TDP-43 might be related to the axonal degeneration in ALS.
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