Nuclear TAR DNA binding protein43 expression correlates with the clinical course in amyotrophic lateral sclerosis.
Project/Area Number |
21591113
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
|
Research Institution | Osaka University |
Principal Investigator |
SUMI Hisae 大阪大学, 医学系・研究科, 助教 (30403059)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 筋萎縮性側索硬化症(ALS) / TDP-43 / 軸索変性 / 上位運動ニューロン / 疾患モデルマウス / 変異SOD1遺伝子(G93A)トランスジェニックマウス / 核外への移行 / TAR DNA-binding protein of 43kDa (TDP-43) / 封入体 / 中心前回 / 核萎縮 / オリゴデンドロサイト / TAR DNA-binding protein of 43kDa(TDP-43) / 細胞核 / 変異SOD1(G93A) / G93Aマウス |
Research Abstract |
The relationship between the aggregation of TDP-43 in the and the degeneration of pyramidal truct in the upper motor neurons was analyzed in ALS cases, which was not significantly observed. In ALS1 model mice, phosphorylated TDP-43 was observed in the white matter of spinal cord, suggesting that TDP-43 might be related to the axonal degeneration in ALS.
|
Report
(4 results)
Research Products
(32 results)