| Project/Area Number |
21591114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Satoshi 九州大学, 大学院・医学研究院, 准教授 (90294917)
OKAMOTO Tsuyoshi 九州大学, 大学院・医学研究院, 准教授 (90432913)
TAKASE Kei-ichiro 九州大学, 大学院・医学研究院, 講師 (00467903)
KAMADA Takashi 九州大学, 大学病院, 学術研究員 (70614460)
UEHARA Taira 九州大学, 大学病院, 臨床助教 (30631585)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | てんかん / 皮質異形成 / ネットワーク / グルタミン酸受容体 / 脳波 / 臨床神経生理学 / フェーズロッキング解析 |
|---|
| Research Abstract |
Applying freeze lesioning in the bilateral frontoparietal lobes during the prenatal period, we developed a cortical dysplasia rat model that can show spontaneous temporal lobe seizures. Immunohistochemical examinations using semiquantitative densitometry revealed the glutamine hyper-excitability at dysplasic lesion accelerate the hippocampal excitability. Phase locking analysis between dysplasic lesion and hippocampus showed the increment of synchronization between these two structures before the start of hippocampal seizure. These findings suggest the excitability in hippocampus increases gradually via the network between cortical dysplasia and hippocampus.
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