| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We examined fine structural changes in motor end plates which anticholinesterase affected in rats with human anti-MuSK or anti-Acethylcholine receptor(AChR) antibodies. The results can usually use anticholinesterase of the consumption in MG with anti-MuSK autoantibody. We also studied the morphological changes in the MG patients with anti-LRP4, anti-MuSK autoantibody or anti-AChR antibodies as the causative autoantibody of MG, An anti-LRP4 antibody and the anti-MuSK autoantibody induce a same change in motor end plate. The motor end plates in the ColQ defect mouse appeared like a change at the time of the anticholinesterase drug overdosage.
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