Effects of the anticholinesterase drug to motor end-plates in myasthenia gravis and changes of the protein which constitutes motor end plate
| Project/Area Number |
21591115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nagasaki University |
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Principal Investigator |
YOSHIMURA Toshiro 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80182822)
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| Co-Investigator(Kenkyū-buntansha) |
MOTOMURA Masakats 長崎大学, 医歯薬学総合研究科, 講師 (70244093)
中野 治郎 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (20380834)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アセチルコリン / MuSK / 抗体陰性 / 運動終板 / ラット / 微細構造 / 重症筋無力症 / 坑コリンエステラーゼ剤 / 治療 / 抗MuSK抗体 / 抗AChR抗体 / 抗LRP抗体 / セルチルコリン / ColQ / 抗コリンエステラーゼ剤 / マウス / Collargen Q |
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| Research Abstract |
We examined fine structural changes in motor end plates which anticholinesterase affected in rats with human anti-MuSK or anti-Acethylcholine receptor(AChR) antibodies. The results can usually use anticholinesterase of the consumption in MG with anti-MuSK autoantibody. We also studied the morphological changes in the MG patients with anti-LRP4, anti-MuSK autoantibody or anti-AChR antibodies as the causative autoantibody of MG, An anti-LRP4 antibody and the anti-MuSK autoantibody induce a same change in motor end plate. The motor end plates in the ColQ defect mouse appeared like a change at the time of the anticholinesterase drug overdosage.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy : histologic and MRI study2010
Author(s)
Nakamura H, Okada A, Kawakami A, Yamasaki S, Ida H, Masuda T, Fukuda T, Satoh K, Yoshimura T, Nakashima M, Hayashi T, Eguchi K
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Journal Title
Rheumatology international
Volume: 30(10)
Pages: 1381-1383
NAID
Related Report
Peer Reviewed
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[Journal Article] Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy : histologic and MRI study.2010
Author(s)
Nakamura H, Okada A, Kawakami A, Yamasaki S, Ida H, Masuda T, Fukuda T, Satoh K, Yoshimura T, Nakashima M, Hayashi T, Eguchi K
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Journal Title
Rheumatology international
Volume: 30(10)
Pages: 1381-1383
NAID
Related Report
Peer Reviewed
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[Presentation] Significance of fine structures in motor end-plate in mice with a collagenous sub-unit called Q(ColQ)-deficient mutant mice2010
Author(s)
Yoshimura T, Ito M, Honda Y, Fukudome T, Eric K, Okada N, Takeda S, Motomura M, Tsujino A, Masuda T, Fukuda T, Yoshimura S, Ohno K
Organizer
12th International Congress on Neuromuscular Diseases
Place of Presentation
Naples
Related Report
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[Presentation] Significance of fine structures in motor end-plate in mice with a collagenous sub-unit called Q(ColQ)-deficient mutant mice.2010
Author(s)
Yoshimura T, Ito M, Honda Y, Fukudome T, Eric K, Okada N, Takeda S, Motomura M, Tsujino A, Masuda T, Fukuda T, Yoshimura S, Ohno K.
Organizer
12th International Congress on Neuromuscular Diseases
Place of Presentation
Naples, Italy
Related Report
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