Cortical modulation by quadripulse transcranial magnetic stimulation (QPS) in benign myoclonus epilepsy patients and intractable epilepsy patients
Project/Area Number |
21591116
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Fukushima Medical University |
Principal Investigator |
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Project Period (FY) |
2009-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2009: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
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Keywords | 不均一連発磁気刺激 / ミオクローヌスてんかん / 難治性てんかん / 磁気刺激 / 体性感覚誘発電位 / てんかん / 不均一連発時期刺激 / 連発磁気刺激 / QPS / quadripulse stimulation |
Research Abstract |
In normal subjects, QPS over M1 inhibited the somatosensory cortex. We compared the effects of quadripulse transracial magnetic stimulation (QPS) on the median nerve somatosensory evoked potential (SEP) between patients with benign myoclonus epilepsy (ME) and normal subjects. In ME patients, any QPSs over M1 induced LTP like effects on S1 with no LTD like effects, which may be explained by a lack of LTD like mechanisms in ME patients. Additionally, we studied the QPS effects upon the cortical function of the intractable epilepsy patients. As the results, QPS did not inhibit the cortical function. We should take care in applying some plasticity induction method in patients because the frequency dependency may be completely different from those of normal subjects in some disorders. Even though, the results indicated characteristic cortical function of the patients.
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Report
(6 results)
Research Products
(28 results)
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[Journal Article] Cortical hemoglobin concentration changes underneath the coil after single-pulse transcranial magnetic stimulation: a near-infrared spectroscopy study.2013
Author(s)
Furubayashi T, Mochizuki H, Terao Y, Arai N, Hanajima R, Hamada M, Matsumoto H, Nakatani-Enomoto S, Okabe S, Yugeta A, Inomata-Terada S, Ugawa Y.
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Journal Title
J Neurophysiol
Volume: 109
Issue: 6
Pages: 1626-1637
DOI
Related Report
Peer Reviewed
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[Journal Article] Bidirectional modulation of sensory cortical excitability by quadripulse transcranial magnetic stimulation (QPS) in humans2012
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Terao Y, Matsumoto H, Shirota Y, Okabe S, Hirose M, Nakamura K, Furubayashi T, Kobayashi S, Mochizuki H, Enomoto H, Ugawa Y
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Journal Title
Clin Neurophysiol
Volume: 123
Pages: 1415-1421
Related Report
Peer Reviewed
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[Journal Article] Some evidence supporting the safety of quadripulse stimulation (QPS)2011
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Mochizuki H, Kobayashi S, Enomoto H, Sugiura Y, Matsumoto H, Furubayashi T, Terao Y, Sato F, Ugawa Y
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Journal Title
Brain Stimul
Volume: 4
Pages: 303-305
Related Report
Peer Reviewed
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[Presentation] Somatosensory evoked potential (SEP) modulation by quadripulse transcranial magnetic stimulation (QPS) in benign myoclonus epilepsy patients2014
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Matsumoto H, Shirota Y, Ohminami S, Okabe S, Terao Y, Furubayashi T, Hirose M, Nakamura K, Groiss SJ, Kobayashi S, Kadowaki S, Mochizuki H, Enomoto H, Ugawa Y
Organizer
ICCN
Related Report
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[Presentation] Bidirectional human sensory cortical excitability modulation by quadripulse magnetic stimulation (QPS) of various cortical areas2010
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Terao Y, Matsumoto H, Hirose M, Nakamura K, Furubayashi T, Mochizuki H, Enomoto H, Ugawa Y
Organizer
ICCN
Related Report
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[Presentation] Bidirectional human sensory cortical excitability modulation by quadripulse magnetic stimulation (QPS) applied over primary motor cortex2010
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Matsumoto H, Terao Y, Furubayashi T, Hirose M, Nakamura K, Mochizuki H, Enomoto H, Ugawa Y
Organizer
Synaptic plasticity from bench to bedside
Related Report
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[Presentation] Somatosensory evoked potential (SEP) modulation by quadripulse transcranial magnetic stimulation (QPS) in benign myoclonus epilepsy patients
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Terao Y, Matsumoto H, Shirota Y, Ohminami S, Okabe S, Groiss SJ, Hirose M, Nakamura K, Furubayashi T, Kobayashi S, Mochizuki H, Enomoto H, Ugawa Y.
Organizer
International Congress on Clinical Neurophysiology
Place of Presentation
Berlin, German
Related Report
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