Integrated Functional Tests of Sensory-Emotional-Autonomic System Using Multimodality Visual Stimulation

• Project/Area Number: 21591117
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Yokohama City University
• Principal Investigator: KUROIWA Yoshiyuki 横浜市立大学, 医学研究科, 教授 (40135249)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Yume 横浜市立大学, 附属病院, 教授 (70236024) ; KOYANO Shigeru 横浜市立大学, 医学部, 准教授 (50315818)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: oddball課題 / S1-S2課題 / 選択的視覚注意課題 / 視覚誘発電位(P1) / 分配的視覚注意課題 / 視覚性事象関連電位(P3) / 錯視刺激 / 立体視刺激

Research Abstract

We obtained dataon normative waveforms of pattern reversal VEPs. New findings were obtained on attensio-raked potentiaks. We found methods to evaluate cerebral functions during stereoscopic(3D) visual stimulation using Integral Imaging Method, or Illusory Streoscopic Imaging method. We could evluate emotional disorders in Parkinson disease. Myerson sign was studied to research on impaired habitution. Somatosensory evoked potentiakswere measured in 120 patients with varous involun tary.

Research Products

• [Journal Article] Modulation of human visual evoked potentials in three-dimensional perception after stimuli produced with an integral imaging method (2012)
  • Author(s): Omoto S, Kuroiwa Y, Otsuka S, Baba Y, Wang C, Li M, Mizuki N, Ueda N, Koyano S, Suzuki Y, Nagatani H, Hirayama Y
  • Journal Title: Clinical EEG and Neuroscience
  • Peer Reviewed
• [Journal Article] Homozygous c. 14576G> A Variant of<I> RNF213</I> Predicts Early-Onset and Severe Form of Moyamoya Disease (2012)
  • Author(s): Miyatake S, Miyake N, Touho H, Nishimura-T, A, Kondo Y, Okada ; I, Tsurusaki ; Y, Doi H, Sakai H, Saitsu ; H, Shimojima K, Yamamoto T, Higurashi M, Kawahara, N, Kawauchi, H, Nagasaka, K, Okamoto N, Mori, T, Koyano S, Kuroiwa Y, Taguri M, Morita S, Matsuba S, Kure S, Matsumoto N
  • Journal Title: Neurology Volume: 78(11) Issue: 11 Pages: 803-10
  • DOI: 10.1212/wnl.0b013e318249f71f
  • Peer Reviewed
• [Journal Article] Modulation of human visual evoked potentials in three-dimensional perception after stimuli produced with an integral imaging method (2012)
  • Author(s): Omoto S
  • Journal Title: Clinical EEG and Neuroscience Volume: (In press)
  • Peer Reviewed
• [Journal Article] Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel cortex (2011)
  • Author(s): Miyazaki T, Kunii M, Tada H, Sano A, Kuroiwa Y, Goto T, Malinow R, Takahashi T
  • Journal Title: Brain Research Volume: 30-1435 Pages: 1-7
  • DOI: 10.1016/j.brainres.2011.11.033
  • Peer Reviewed
• [Journal Article] Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation (2011)
  • Author(s): Doi H, Yoshida K, Yasuda T, Fukuda M, Morita R, Ikeda S, Kato R, Tsurusaki Y, Miyake N, Saitsu H, Sakai H, Miyatake S, Shiina M, Nukina N, Koyano S, Tsuji S, Kuroiwa Y, Matsumoto N
  • Journal Title: Am J Hum Genet Volume: 89(2) Pages: 320-7
  • Peer Reviewed
• [Journal Article] 脳機能計測法を基礎から学ぶ人のために (2011)
  • Author(s): 黒岩義之, 三谷博子
  • Journal Title: 長ループ反射.臨床神経生理学 Volume: 39 Pages: 521-528
• [Journal Article] 「脳機能計測法を基礎から学ぶ人のために」交感神経皮膚反応 (2011)
  • Author(s): 黒岩義之, 三谷博子
  • Journal Title: 臨床神経生理学 Volume: 39 Pages: 529-534
• [Journal Article] パソコンソフトを用いた小脳性運動失調の評価(第6報).厚生労働科学研究費補助金難治性疾患克服研究事業 (2011)
  • Author(s): 黒岩義之, 上田直久, 波木井靖人
  • Journal Title: 運動失調症の病態解明と治療法開発に関する研究班平成22年度総括・分担研究報告書 Pages: 58-60
• [Journal Article] Dementia and capsular genu ischemia in patientswith severe bacterial meningitis (2010)
  • Author(s): Naito M, Johkura K, Momoo T, Nomiya T, Kudo Y, Kuroiwa Y
  • Journal Title: Neurol Sci Volume: 31(13) Issue: 2 Pages: 3-136
  • DOI: 10.1007/s10072-009-0168-x
  • Peer Reviewed
• [Journal Article] The RNA-binding protein FUS/TLS is a common aggregateinteractingprotein in polyglutamine diseases (2010)
  • Author(s): Doi H, Koyano S, Suzuki Y, Nukina N, Kuroiwa Y
  • Journal Title: NeurosciRes Volume: 66 Issue: 1 Pages: 131-133
  • DOI: 10.1016/j.neures.2009.10.004
  • Peer Reviewed
• [Journal Article] Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and anovel mutation, Ile346Ser, in PANK2 : clinical featuresand(99m) Tc-ECD brain perfusion SPECT findings (2010)
  • Author(s): Doi H, Koyano S, Miyatake S, Matsumoto N, Kameda T, Tomita A, Miyaji Y, Suzuki Y, Sawaishi Y, Kuroiwa Y
  • Journal Title: JNeurol Sci Volume: 290 Issue: 1-2 Pages: 172-176
  • DOI: 10.1016/j.jns.2009.11.008
  • Peer Reviewed
• [Journal Article] P1and P2componentsof human visual evoked potentials are modulated by depth perception of 3-dimensional images (2010)
  • Author(s): Omoto S, Kuroiwa Y, Otsuka S, Baba Y, Wang C, Li M, Mizuki N, Ueda N, Koyano S, Suzuki Y
  • Journal Title: Clinical Neurophysiology Volume: 121 Pages: 386-391
  • Peer Reviewed
• [Journal Article] prion disease in Japan (2010)
  • Author(s): Nozaki I, Hamaguchi T, Sakai K, Noguchi-Shinohara M, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Sanjo N, Morikawa F, Shiga Y, Kuroiwa Y, Nishizawa M, Kuzuhara S, Inuzuka T, Takeda M, Kuroda S, Abe K, Murai H, Murayama S, Tateishi J, Takumi I, Sirabe S, Harada M
  • Journal Title: Brain Volume: 133 Issue: 10 Pages: 3043-3057
  • DOI: 10.1093/brain/awq216
  • Peer Reviewed
• [Journal Article] Electrophysiologicalanalysis of Myerson sign in Parkinson's disease (2010)
  • Author(s): Uematsu E, Kishida H, Nakano T, Iwahashi Y, Ueda N, Koyano S, Suzuki Y, Kuroiwa Y
  • Journal Title: Journal of Neurology Volume: 257
• [Journal Article] Statistical analysis of VEPs to transient full-field pattern-reversal stimulation in 167 normal adults (2010)
  • Author(s): Otsuka S, Kuroiwa Y, Omoto S, Baba Y
  • Journal Title: Clinical Neurophysiology Volume: 121
• [Journal Article] P1 and P2 components of human visual evoked potentials are modulated by depth perception of 3-dimensional images (2010)
  • Author(s): Omoto S
  • Journal Title: Clinical Neurophysiology Volume: 121 Pages: 386-391
  • Peer Reviewed
• [Journal Article] Dementia and capsular genu ischemia in patients with severe bacterial meningitis. (2010)
  • Author(s): Naito M
  • Journal Title: Neurol Sci. Volume: 31(2) Pages: 133-136
  • Peer Reviewed
• [Journal Article] Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2 : clinical features and(99m)Tc-ECD brain perfusion SPECT findings. (2010)
  • Author(s): Doi H
  • Journal Title: J Neurol Sci Volume: 290(1,2) Pages: 172-176
  • Peer Reviewed
• [Journal Article] Visual event-related potential changes in multiple system atrophy : Delayed N2 latency in selective attention to a color task (2009)
  • Author(s): Kamitani T
  • Journal Title: Journal of the Neurological Sciences 15 Pages: 36-40
  • Peer Reviewed
• [Journal Article] P1 and P2 components of human visual evoked potentials are modulated by depth perception of 3-dimensionalimages (2009)
  • Author(s): Omoto S
  • Journal Title: Clinical Neurophysiology 121 Pages: 386-391
  • Peer Reviewed
• [Journal Article] Attentional modulations of event-related potentials examined for a visual oddball task performed continuously for a period of 150 seconds (2009)
  • Author(s): Wang C
  • Journal Title: 自律神経 46(2) Pages: 90-97
  • Peer Reviewed
• [Presentation] 視覚誘発電位の特徴に関する研究:二次元刺激と三次元刺激の比較 (2011)
  • Author(s): 黒岩義之
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場愛知県
  • Year and Date: 2011-05-20
• [Presentation] 視覚誘発電位の特徴に関する研究:二次元刺激と三次元刺激の比較 (2011)
  • Author(s): 黒岩義之, 尾本周, 馬場泰尚, 児矢野繁, 鈴木ゆめ
  • Organizer: 第52回日本神経学会総会
  • Place of Presentation: 名古屋
• [Presentation] Cognitive VEPs. (2010)
  • Author(s): Kuroiwa Y
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-10-29
• [Presentation] 会長講演 日常生活から見た神経学 (2010)
  • Author(s): 黒岩義之
  • Organizer: 第28回日本神経治療学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-07-15
• [Presentation] シンポジウム22 医療経済的基盤と制度変革 包括医療制度と神経生理学検査の話題を中心に (2010)
  • Author(s): 黒岩義之
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-22
• [Presentation] 口演 各種不随意運動患者121例における体性感覚誘発電位と長経路反射 (2010)
  • Author(s): 黒岩義之
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-22
• [Presentation] 各種不随意運動患者121例における体性感覚誘発電位と長経路反射 (2010)
  • Author(s): 黒岩義之
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 日常生活から見た神経学 (2010)
  • Author(s): 黒岩義之
  • Organizer: 第28回日本神経治療学会総会
  • Place of Presentation: 横浜
• [Presentation] 「平成22年度総務省が実施する情報通信分野の研究開発に関する追跡調査-映像が生体に与える悪影響を防止する技術-」に関する現在までの調査結果 (2010)
  • Author(s): 黒岩義之
  • Organizer: 快適3D基盤研究推進委員会
  • Place of Presentation: 東京
• [Presentation] 3D映像の生体安全性について:臨床医の立場から (2010)
  • Author(s): 黒岩義之
  • Organizer: CEATEC JAPAN2010
  • Place of Presentation: 幕張
• [Presentation] 健康成人167例における transient 型全視野パターン反転VEPの統計解析 (2009)
  • Author(s): 大塚菜花
  • Organizer: 第39回日本臨床神経生理学会学術大会
  • Place of Presentation: 北九州市
  • Year and Date: 2009-11-19
• [Presentation] 各種不随意運動患者121例における体性感覚誘発電位と長経路反射 (2009)
  • Author(s): 黒岩義之
  • Organizer: 第39回日本臨床神経生理学会学術大会
  • Place of Presentation: 北九州市
  • Year and Date: 2009-11-18
• [Presentation] 運動症候の左右差から見たパーキンソン病の非運動症候:自験140例の検討 (2009)
  • Author(s): 黒岩義之
  • Organizer: 第27回日本神経治療学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2009-06-12
• [Presentation] 視覚情報処理における疲労:健康成人・多発性硬化症における検討 (2009)
  • Author(s): 黒岩義之
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-20