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Experimental studies on the therapeutic efficacies of zonisamide on Parkinson disease

Research Project

Project/Area Number 21591118
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionWakayama Medical University

Principal Investigator

MIWA Hideto  和歌山県立医科大学, 医学部, 准教授 (50231626)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Ichiro  和歌山県立医科大学, 医学部, 助教 (40364088)
近藤 智善  和歌山県立医科大学, 医学部, 教授 (50103891)
Co-Investigator(Renkei-kenkyūsha) KONDO Tomoyoshi  和歌山県立医科大学, 医学部, 教授 (50103891)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsゾニザミド / 振戦 / パーキンソン病 / T型カルシウムチャンネル / ゾニサミド / ドパミン / ハルマリン / モノアミン酸化酵素
Research Abstract

Zonisamide is an anti-epileptic drug, and it can be used for treatment of Parkinson disease(PD). However, the pharmacological mechanisms underlying the anti-parkinsonian effects remain unclear. In the present study, we performed animal experiments using experimental tremor models, and could obtain data suggesting that not only zonisamide but also the other T-type calcium channel blockers have the anti-tremor effect. It is expected that T-type calcium channel would be a new therapeutic target of tremors.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats2011

    • Author(s)
      Miwa H, Koh J, Kajimoto Y, Kondo T
    • Journal Title

      Pharmacology Biochemistry & Behavior

      Volume: 97 Pages: 656-659

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] T-type calcium channel as a new therapeutic target for tremor2011

    • Author(s)
      Miwa H and Kondo T
    • Journal Title

      Cerebellum

      Volume: 10 Pages: 563-569

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of T-type calcium channel blockers on a parkinsonian tremormodel in rats.2011

    • Author(s)
      Miwa H, Jinsoo Koh, Kajimoto Y, Kondo T.
    • Journal Title

      Pharmacol Riochem Behav

      Volume: 97 Pages: 656-659

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats : a potential mechanism underlying its antiparkinsonian tremor effect2009

    • Author(s)
      Miwa H, Kubo T, Suzuki A and Kondo T
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 15 Pages: 33-35

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats : a potential mechanism underlying its anti-parkin sonian tremor effect2009

    • Author(s)
      Miwa H, Kubo T, Suzuki A, et al.
    • Journal Title

      Parkinsonism Relat Disord 15

      Pages: 33-35

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] T-type calcium channels in the CNS : a new therapeutic target for tremor2011

    • Author(s)
      Miwa H, Koh J, Kajimoto Y, Kondo T
    • Organizer
      The 15th International Congress of Parkinson's disease and Movement Disorders
    • Place of Presentation
      トロント
    • Year and Date
      2011-06-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] T-type calcium channels in the CNS : a new therapeutic target for tremor2011

    • Author(s)
      Miwa H, Koh J, Kajimoto Y, Kondo T
    • Organizer
      The 15th International Congress of Parkinson's disease and Movement Disorders
    • Place of Presentation
      Toronto
    • Related Report
      2011 Final Research Report
  • [Presentation] 実験的振戦モデルに対するT型カルシウムチャンネル阻害薬の効果についての検討2010

    • Author(s)
      高真守、梶本賀義、三輪英人、近藤智善
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 実験的パーキンソン病モデルに対するゾニサミドの効果2009

    • Author(s)
      三輪英人, 中西一郎, 久保友美, ほか
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンポジウム:Motor fluctuation の新展開とゾニサイドの位置づけ2009

    • Author(s)
      三輪英人
    • Organizer
      第17回カテコールアミンと神経疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of zonisamide on experimental parkinsonian tremors in rats2009

    • Author(s)
      Miwa H, Kubo T, Hama-Kobayashi K, Kajimoto Y, Kondo T
    • Organizer
      The 13th International Congress of Parkinson's disease and Movement Disorders
    • Place of Presentation
      Paris
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] シンポジウム: Motor fluctuationの新展開とゾニサイドの位置づけ2009

    • Author(s)
      三輪英人
    • Organizer
      第17回カテコールアミンと神経疾患研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 実験的パーキンソン病モデルに対するゾニサミドの効果2009

    • Author(s)
      三輪英人、中西一郎、久保友美、近藤智善
    • Organizer
      第50回日本神経学会
    • Place of Presentation
      仙台
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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