| Project/Area Number |
21591122
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
ISHIGAKI Yasushi 東北大学, 大学院・医学系研究科, 准教授 (50375002)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
GAO Junhong 東北大学, 大学院・医学系研究科, 助教 (70455781)
SAWADA Shoujirou 東北大学, 大学院・医学系研究科, 助教 (60509420)
YAMAGUCHI Suguru 日本大学, 医学部, 助教 (70451614)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 動脈硬化 / 小胞体ストレス / 酸化ストレス / 炎症 |
|---|
| Research Abstract |
The processes of arteriosclerosis are affected by interactions among numerous biological pathways, such as responses to inflammation, oxidative stress and endoplasmic reticulum (ER)stress. C/EBP homologous protein (CHOP), which is well known to induce cellular apoptosis in response to severe ER stress, is reportedly up-regulated in plaque lesions. Cuff injury-induced neointimal formation and hypercholesterolemia-induced aortic plaque formation were markedly inhibited in CHOP-/-mice with suppressed aortic expressions of inflammatory factors and oxidative stress markers. CHOP may play important roles in augmenting potentially pathological biological stress responses and contribute to the progression of vascular remodeling and atherosclerosis.
|
