| Project/Area Number |
21591126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Toyama |
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Principal Investigator |
TOBE Kazuyuki 富山大学, 大学院・医学薬学研究部(医学), 教授 (30251242)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJISAKA Shiho 富山大学, 大学病院, 医員 (30512082)
KOSHIMIZU Yukiko 富山大学, 大学院・医学薬学研究部(医学), 助教 (30511828)
SHINODA Kouichirou 富山大学, 大学院・医学薬学研究部(医学), 助教 (40377312)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 肥満 / 脂肪組織 / 炎症 / インスリン抵抗性 / マクロファージ |
|---|
| Research Abstract |
In obese adipose tissues, the number of inflammatory M1 macrophage is dramatically increased and the ratio of antiinflammatory M2 macrophage is reduced, resulting the decrease of insulin sensitivity and development of obesity complications(Diabetes 58 : 2574-2582, 2009). I found that telmisartan, an angiotensin II type I receptor blocker, improved insulin resistance with its PPARγactivity, by modulating M1/M2 macrophage ratio(Endocrinology, 152 : 1789-1799, 2011). I also found that obesity-induced hypoxia in adipose tissue is involved in M1 polarization of macrophages.
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