| Project/Area Number |
21591130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
|
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
ISSHIKI Keiji 滋賀医科大学, 医学部, 助教 (60378487)
|
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Shiro 独立行政法人理化学研究所, 内分泌代謝疾患研究チーム, チームリーダー (50314159)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
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| Keywords | Acetyl-CoA carboxylase beta(ACCβ) / 5' AMP-activated protein kinase(AMPK) / 糸球体上皮細胞 / 糖尿病性腎症 / 腎内脂肪毒性 / Acetyl-CoA carboxylase beta (ACCβ) / 5' AMP-activated protein kinase (AMPK) / 糖尿病 / 脂質 / 脂質代謝異常 |
|---|
| Research Abstract |
Podocyte-specific overexpression of ACCbeta, a lipogenic enzyme, causes apoptosis, inflammation and reduction of slit-diaphragm proteins in podocytes. These structural and functional abnormalities in podocytes are related to the increase of albuminuria. The activation of AMPK, which suppresses the activity of ACCbeta, may be a new therapeutic target of podocyte injury in diabetic nephropathy by inhibiting the activity of ACCbeta in podocytes
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