| Project/Area Number |
21591132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kyoto University |
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Principal Investigator |
SEINO Yutaka 京都大学, 医学研究科, 名誉教授 (40030986)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAMOTO Yoshiyuki 公益財団法人田附興風会医学研究所, 北野病院・第3研究部, 研究員 (50390787)
TOYODA Kentarou 京都大学, 医学研究科, 助教 (00447971)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANE Shunsuke 京都大学, 医学研究科, 特定助教
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | エネルギー / 糖質代謝異常 / インクレチン / アポトーシス / ERストレス / CHOP / Bip / XBP-1 |
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| Research Abstract |
Endoplasmic reticulum stress(ERS) is one of the contributing factors in the development of type 2 diabetes. Exendin-4(Ex-4), a potent GLP-1 receptor agonist, significantly reduced blood glucose levels and preservedυ-cell mass and the number of islets in Akita mice, an animal model of ER stress-mediated diabetes. Since there was no such effect observed in the mice treated with phlorizin, an insulin-independent glucose-lowering drug, the effects were suggested to be independent of glucose-lowering effect of Ex-4. Akita mice treated with Ex-4 showed a significant decrease in apoptosis ofυ-cells and significantly reduced CHOP mRNA and protein levels inυ-cells, suggesting thatυ-cell protective effects of Ex-4 were achieved mainly through a reduction of ER stress-mediatedυ-cell damage and apoptotic cell death.
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