Investigation of the mechanism by which FSP27 can efficiently store triglyceride as intracellular lipid droplets.
| Project/Area Number |
21591136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
TAMORI Yoshikazu 神戸大学, 大学院・医学研究科, 戦略的客員教授 (90379397)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞内脂肪滴 / FSP27結合蛋白 / 脂肪滴蛋白質 / 質量分析法 |
|---|
| Research Abstract |
We performed the structure-function analysis of FSP27 to clarify the mechanism by which FSP27 increases the size of lipid droplet in adipocytes. We found that the COOH-terminal domain(amino acid : 130-239) of mouse FSP27 was necessary and enough to increase the size of lipid droplet. In addition, we showed that this domain of FSP27 interacted with each other as the full length of FSP27 did. We suppose that FSP27 on lipid droplets can drive the fusion of lipid droplets by interacting with each other through the COOH-terminal domain.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue2012
Author(s)
Matsubara T, Mita A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E, Nishimura O, Seino S
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Journal Title
Cell Metab
Volume: 15
Pages: 38-50
Related Report
Peer Reviewed
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[Journal Article] Seino S PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue2011
Author(s)
Matsubara T, Mita A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E, Nishimura O
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Journal Title
Cell Metab
Volume: 15
Pages: 38-50
Related Report
Peer Reviewed
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[Journal Article] Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma2010
Author(s)
Ueda S, Kitazawa S, Ishida K, Nishikawa Y, Matsui M, Matsumoto H, Aoki T, Nozaki S, Takeda T, Tamori Y, Aiba A, Kahn RC, Kataoka T, Satoh T
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Journal Title
FASEB J
Volume: 24
Pages: 2254-2261
Related Report
Peer Reviewed
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