Elucidation of molecular basis of pancreatic beta-cell regeneration from pancreatic acinar cells
| Project/Area Number |
21591137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
MINAMI Kohtaro 神戸大学, 大学院・医学研究科, 准教授 (80334176)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | エネルギー / 糖代謝異常 / 再生医療 / 膵腺房細胞 / インスリン / 膵β細胞 / 糖尿病 / 細胞内シグナル |
|---|
| Research Abstract |
Generation of surrogate beta-cells(insulin-secreting cells) is a promising approach toward development of regenerative medicine in diabetes mellitus. In this study, it has been shown that insulin-secreting cells can be generated from human pancreatic exocrine cells. It also has been found that pancreatic beta-cells change their phenotype(dedifferentiation, proliferation, and redifferentiation) under certain conditions. In addition, it has been revealed that new pancreatic beta-cells are generated by neogenesis form non-beta-cells in vivo after birth.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] PGRN is a key adipokine mediating high-fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue2012
Author(s)
Matsubara T, Kagawa A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E, Nishimura O, and Seino S
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Journal Title
Cell Metab
Volume: 15(1)
Pages: 38-50
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[Journal Article] Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.2010
Author(s)
Tanaka H, Fukamachi K, Futakuchi M, Alexander DB, Long N, Tamamushi S, Minami K, Seino S, Ohara H, Joh T, Tsuda H
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Journal Title
Cancer Sci 101
Pages: 341-346
Related Report
Peer Reviewed
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