Epigenetic models of insulin resistance targeting the human resistin gene

• Project/Area Number: 21591141
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Ehime University
• Principal Investigator: OSAWA Haruhiko 愛媛大学, 大学院・医学系研究科, 教授 (90294800)
• Co-Investigator(Kenkyū-buntansha): ONUMA Hiroshi 愛媛大学, 大学院医学系研究科, 准教授 (00294794) ; NISHIDA Wataru 愛媛大学, 大学院医学系研究科, 講師 (80271089) ; TAKATA Yasunori 愛媛大学, 医学部附属病院, 講師 (20432792) ; TABARA Yasuharu 愛媛大学, 医学部附属病院, 講師 (00268749)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: レジスチン / インスリン抵抗性 / SNP / エピジェネティクス / 遺伝子発現 / 2型糖尿病

Research Abstract

Resistin causes insulin resistance, a feature of type 2 diabetes. We analyzed genetic and environmental factors affecting resistin gene expression. In～2000 subjects in the Japanese general population, plasma resistin was low with G at single nucleotide polymorphism(SNP)-420 and G at SNP-358, but highest with G at SNP-420 and A at SNP-358. This combination of these SNPs also showed the highest promoter activity. Therefore, A at SNP-358 is required for G at SNP-420 to confer the highest plasma resistin.

Research Products

• [Journal Article] ヒトにおけるレジスチンの意義 (2011)
  • Author(s): 大沼裕、大澤春彦
  • Journal Title: 実験医学 Volume: 29 Pages: 715-721
  • Peer Reviewed
• [Journal Article] 生活習慣病における遺伝因子-2型糖尿病を中心に- (2011)
  • Author(s): 大澤春彦
  • Journal Title: 日本体質医学会雑誌 Volume: 73 Pages: 41-46
  • Peer Reviewed
• [Journal Article] Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population? (2010)
  • Author(s): Osawa, H., Tabara, Y., Ohashi, J., Kawamura, R., Onuma, H., and Makino, H.
  • Journal Title: Diabetologia Volume: 53 Pages: 795-797
  • Peer Reviewed
• [Journal Article] A at single nucleotide polymorphism-358 is required for G at-420 to confer the highest plasma resistin in the general Japanese population (2010)
  • Author(s): Onuma, H., Tabara, Y., Kawamura, R., Tanaka, T., Ohashi, J., Nishida, W., Takata, Y., Ochi, M., Yamada, K., Kawamoto, R., Kohara, K., Miki, T., Makino, H., and Osawa, H.
  • Journal Title: PLoS ONE Volume: 5
  • Peer Reviewed
• [Journal Article] レジスチンの臨床的意義 (2010)
  • Author(s): 大沼裕, 大澤春彦
  • Journal Title: Annual Review糖尿病・代謝・内分泌 Pages: 138-144
  • Peer Reviewed
• [Journal Article] レジスチン (2010)
  • Author(s): 大沼裕, 大澤春彦
  • Journal Title: 日本臨床 Volume: 68(増刊号2) Pages: 100-104
  • NAID: 40020522158
  • Peer Reviewed
• [Journal Article] レジスチンの臨床的意義 (2010)
  • Author(s): 大沼裕, 大澤春彦
  • Journal Title: Annual Review 糖尿病・代謝・内分泌 2010巻 Pages: 138-144
• [Journal Article] レジスチン (2010)
  • Author(s): 大沼裕, 大澤春彦
  • Journal Title: 日本臨末 増刊号2 肥満症 68巻 Pages: 100-104
  • NAID: 40020522158
• [Presentation] 血中レジスチンはレジスチン遺伝子のSNP-420、SNP-358により強く規定される一方、2型糖尿病感受性遺伝子のトランス作用によっても影響される (2011)
  • Author(s): 大沼裕, 田原康玄, 西田亙, 高田康徳, 大澤春彦, 他
  • Organizer: 第61回日本体質医学会総会
  • Place of Presentation: 東京
• [Presentation] 生活習慣病における遺伝因子-2型糖尿病を中心に- (2010)
  • Author(s): 大澤春彦
  • Organizer: 第60回日本体質医学会総会
  • Place of Presentation: 熊本
• [Presentation] Relevance of resistin in human insulin resistance (2009)
  • Author(s): Hiroshi Onuma, Haruhiko Osawa et al
  • Organizer: The 2^<nd> Insulin resistance in metabolic disease forum
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2009-10-31
• [Remarks]
  • URL: http://www.m.ehime-u.ac.jp/school/clab/index.html