| Project/Area Number |
21591143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Nagasaki University |
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Principal Investigator |
ABIRU Norio 長崎大学, 大学院・医歯薬学総合研究科, 講師 (00380981)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Masakazu 長崎大学, 医歯薬学総合研究科, 客員研究員 (00380874)
SATOH Tsuyoshi 長崎大学, 大学病院, 医員 (70437896)
KURIYA Genpei 長崎大学, 大学病院, 医員 (50457579)
NAKAMURA Kan 長崎大学, 大学病院, 医員 (70530426)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAYAMA Yuji 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30274632)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 1型糖尿病 / NODマウス / インスリン / 経鼻免疫 / polyI : C / 発症予防 / poly I:C / poly:IC / インスリンペプチド / 膵島自己抗原 |
|---|
| Research Abstract |
In order to develop the treatment for the inhibition of type 1 diabetes, we evaluated the combination treatments with intra-nasal(i. n.) and subcutaneous(sub-Q) autoantigen administration for diabetes inhibition in the NOD mice. The mice treated with combination of i. n. insulin B-chain peptide/ polyI : C and a single sub-Q insulin peptide/ Alum exhibited less development of diabetes compared to those with single subQ-peptide/ Alum alone or control mice. However, such combination treatments did not alter population of regulatory T cells.
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