| Project/Area Number |
21591148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
KOYA Daisuke 金沢医科大学, 医学部, 教授 (70242980)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | エネルギー / 糖代謝異常 / 糖尿病腎症 / レスベラトロール / カロリー制限 / プロテオーム解析 / オートファジー / ミトコンドリア / 酸化ストレス / 加齢腎 / Mn-SOD |
|---|
| Research Abstract |
Here, we hypothesized that mitochondria dysfunction due to aging-and diabetes-induced sirtuin 1(SIRT1) down regulation could result in renal inflammation, increased oxidative stress, and finally renal pathologies. Firstly, calorie restriction exerts anti-inflammatory effects and improves the dysregulation of autophagy through the restoration of SIRT1 in the aging kidneys, resulting in the amelioration of renal injuries. Secondly, resveratrol(RSV) ameliorates renal injury and enhanced mitochondrial biogenesis with Mn-SOD dysfunction in the kidney of db/db mice, through improvement of oxidative stress via normalization of Mn-SOD function and glucose-lipid metabolism via AMPK/SIRT1-independent pathway. Thirdly, calorie restriction exerts anti-inflammatory effects and improves the dysregulation of autophagy through the restoration of SIRT1 in the kidneys of WFRs, resulting in the amelioration of renal injuries in type 2 diabetes.
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