New therapeutic strategy for diabetic nephropathy
Project/Area Number |
21591148
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Kanazawa Medical University |
Principal Investigator |
KOYA Daisuke 金沢医科大学, 医学部, 教授 (70242980)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | エネルギー / 糖代謝異常 / 糖尿病腎症 / レスベラトロール / カロリー制限 / プロテオーム解析 / オートファジー / ミトコンドリア / 酸化ストレス / 加齢腎 / Mn-SOD |
Research Abstract |
Here, we hypothesized that mitochondria dysfunction due to aging-and diabetes-induced sirtuin 1(SIRT1) down regulation could result in renal inflammation, increased oxidative stress, and finally renal pathologies. Firstly, calorie restriction exerts anti-inflammatory effects and improves the dysregulation of autophagy through the restoration of SIRT1 in the aging kidneys, resulting in the amelioration of renal injuries. Secondly, resveratrol(RSV) ameliorates renal injury and enhanced mitochondrial biogenesis with Mn-SOD dysfunction in the kidney of db/db mice, through improvement of oxidative stress via normalization of Mn-SOD function and glucose-lipid metabolism via AMPK/SIRT1-independent pathway. Thirdly, calorie restriction exerts anti-inflammatory effects and improves the dysregulation of autophagy through the restoration of SIRT1 in the kidneys of WFRs, resulting in the amelioration of renal injuries in type 2 diabetes.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Emerging role of autophagy in kidney function, diseases and aging2012
Author(s)
Huber TB, Edelstein CL, Hartleben B, Inoki K, Jiang M, Koya D, Kume S, Lieberthal W, Pallet N, Quiroga A, Ravichandran K, Susztak K, Yoshida S, Dong Z
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Journal Title
Autophagy
Volume: 8(7)
Pages: 1-23
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Peer Reviewed
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[Journal Article] SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells2011
Author(s)
Koyama T, Kume S, Koya D, Araki S, Isshiki K, Chin-Kanasaki M, Sugimoto T, Haneda M, Sugaya T, Kashiwagi A, Maegawa H, Uzu T
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Journal Title
Free Radic Biol Med
Volume: 51(6)
Pages: 1258-67
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Peer Reviewed
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[Journal Article]2010
Author(s)
古家大祐
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Journal Title
糖尿病性腎症。専門医のための腎臓病学 第2版(医学書院)
Pages: 490-499
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